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Journal article
Hormonally regulated α4β2δ GABAA receptors are a target for alcohol
Nature neuroscience, v 5(8), pp 721-722
01 Aug 2002
PMID: 12118257
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Here we report that low concentrations of alcohol (1–3 mM) increased Cl− currents gated by a recombinant GABAA receptor, α4β2δ, by 40–50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing α4 and δ subunits, using a rat model1 of premenstrual2 syndrome (PMS) in which 1–3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of δ-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased2.
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Details
- Title
- Hormonally regulated α4β2δ GABAA receptors are a target for alcohol
- Creators
- Inger Sundstrom-Poromaa - SUNY Downstate Health Sciences UniversityDeborah H. Smith - Memorial Sloan Kettering Cancer CenterQi Hua Gong - SUNY Downstate Health Sciences UniversityThomas N. Sabado - SUNY Downstate Health Sciences UniversityXinshe Li - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)Adam Light - University of ChicagoMartin Wiedmann - Memorial Sloan Kettering Cancer CenterKeith Williams - SUNY Downstate Health Sciences UniversitySheryl S. Smith - SUNY Downstate Health Sciences University
- Publication Details
- Nature neuroscience, v 5(8), pp 721-722
- Publisher
- Springer Nature
- Number of pages
- 2
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:000177088900010
- Scopus ID
- 2-s2.0-0036326314
- Other Identifier
- 991019168422704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences