Journal article
Hormone therapy and physical function change among older women in the Women's Health Initiative: a randomized controlled trial
Menopause (New York, N.Y.), v 17(2), pp 295-302
Mar 2010
PMID: 19858764
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although estrogen may be linked to biological pathways that maintain higher physical function, the evidence is derived mostly from observational epidemiology and therefore has numerous limitations. We examined whether hormone therapy affected physical function in women 65 to 79 years of age at enrollment.
This study involves an analysis of the Women's Health Initiative randomized controlled trials of hormone therapy in which 922 nondisabled women who had previous hysterectomies were randomized to receive estrogen therapy or a placebo and 1,458 nondisabled women with intact uteri were randomized to receive estrogen + progestin therapy or a placebo. Changes in physical function were analyzed for treatment effect, and subgroup differences were evaluated. All women completed performance-based measures of physical function (grip strength, chair stands, and timed walk) at baseline. These measures were repeated after 1, 3, and 6 years.
Overall, participants' grip strength declined by 12.0%, chair stands declined by 3.5%, and walk pace slowed by 11.4% in the 6 years of follow-up (all P values <0.0001). Hormone therapy, as compared with placebo, was not associated with an increased or decreased risk of decline in physical function in either the intention-to-treat analyses or in analyses restricted to participants who were compliant in taking study pills.
Hormone therapy provided no overall protection against functional decline in nondisabled postmenopausal women 65 years or older in 6 years of follow-up. This study did not address the influence of hormone therapy for women of younger ages.
Metrics
Details
- Title
- Hormone therapy and physical function change among older women in the Women's Health Initiative: a randomized controlled trial
- Creators
- Yvonne L Michael - Department of Epidemiology, Drexel University School of Public Health, Philadelphia, PA 19102, USA. michaely@drexel.eduRachel GoldJoAnn E MansonErin M KeastBarbara B CochraneNancy F WoodsRobert G BrzyskiS Gene McNeeleyRobert B Wallace
- Publication Details
- Menopause (New York, N.Y.), v 17(2), pp 295-302
- Publisher
- Lippincott; United States
- Grant note
- 24152 / PHS HHS 32108-9 / PHS HHS 32105-6 / PHS HHS 32122 / PHS HHS 1 R03 AG031973-01 / NIA NIH HHS 32111-13 / PHS HHS 32115 / PHS HHS 42129-32 / PHS HHS 44221 / PHS HHS 32100-2 / PHS HHS 42107-26 / PHS HHS R03 AG031973 / NIA NIH HHS 32118-32119 / PHS HHS N01WH22110 / WHI NIH HHS R03 AG031973-02 / NIA NIH HHS R03 AG031973-01A2 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000275485200015
- Scopus ID
- 2-s2.0-77949352328
- Other Identifier
- 991014877787404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology