Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Hospital-Acquired Hyponatremia in Children Following Hypotonic versus Isotonic Intravenous Fluids Infusion
Children (Basel), v 5(10)
02 Oct 2018
PMID: 30279348
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypotonic solutions have been used in pediatrics for maintenance of intravenous (IV) hydration. However, recent randomized control trials and cohort studies have raised significant concerns for association with hospital-acquired hyponatremia (HAH). The study aimed to assess whether the use of hypotonic parenteral solutions (PS) compared with isotonic PS is associated with increased HAH risk in children with common pediatric conditions. Retrospective chart review of 472 patients aged 2 months to 18 years who received either isotonic or hypotonic PS as maintenance fluids. Administration of hypotonic PS was associated with a four-fold increase in risk of developing HAH in the univariate analysis, (unadjusted odds ratio (OR) = 3.99; 95% confidence interval (CI): 1.36⁻11.69,
0.01). Hypotonic PS were associated with HAH (
= 0.04) when adjusted for the level of admission serum CO₂. There was a mean decrease of serum sodium of 0.53 mEq/L in the hypotonic group compared to the mean increase of 4.88 mEq/L in the isotonic group. These data suggest that hypotonic PS are associated with HAH in children admitted for common pediatric conditions. Isotonic PS should be considered as a safer choice for maintenance fluid hydration.
Metrics
Details
- Title
- Hospital-Acquired Hyponatremia in Children Following Hypotonic versus Isotonic Intravenous Fluids Infusion
- Creators
- Spyridon A Karageorgos - Children's Hospital of PhiladelphiaPanagiotis Kratimenos - George Washington UniversityAshley Landicho - Crozer-Keystone Health SystemJoshua Haratz - St. Christopher's Hospital for ChildrenLouis Argentine - St. Christopher's Hospital for ChildrenAmit Jain - University of South DakotaAndrew D McInnes - Jersey Shore University Medical CenterMargaret Fisher - Drexel UniversityIoannis Koutroulis - Division of Emergency Medicine, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA.
- Publication Details
- Children (Basel), v 5(10)
- Publisher
- MDPI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics; Emergency Medicine
- Web of Science ID
- WOS:000448544400011
- Scopus ID
- 2-s2.0-85107539185
- Other Identifier
- 991019169645804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics