Journal article
Hospital admission with infection during childhood and risk for psychotic illness--a population-based cohort study
Schizophrenia bulletin, v 40(6), pp 1518-1525
Nov 2014
PMID: 24366719
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A growing body of literature suggests that exposure to infections, particularly maternal infections, during pregnancy confers risk for later development of psychotic disorder. Though brain development proceeds throughout childhood and adolescence, the influence of infections during these ages on subsequent psychosis risk is insufficiently examined. The aim of this study was to investigate the potential association between infections during childhood and nonaffective psychoses in a large population-based birth cohort with follow up long enough to include peak incidence of nonaffective psychosis. We included all individuals born in Sweden between 1973 and 1985, (N = 1172879), with follow up on first time inpatient care with nonaffective psychosis from age 14 years until 2006, (N = 4638). Following adjustment for differences in sex, socioeconomic status, family history of psychosis, and hospital admissions involving noninfectious, nonpsychiatric care, we observed a small but statistically significant association between hospital admissions for infections, in general, throughout childhood (0-13 years) and a later diagnosis of nonaffective psychosis, hazard ratio (HR) = 1.10 (95% CI 1.03-1.18), and this association seemed to be driven by bacterial infection, HR = 1.23 (95% CI 1.08-1.40). Bacterial infections and central nervous system infections during preadolescence (10-13 years) conferred the strongest risk, HR 1.57 (95% CI 1.21-2.05) and HR 1.96 (95% CI 1.05-3.62), respectively. Although preadolescence appeared to be a vulnerable age period, and bacterial infection the most severe in relation to psychosis development, the present findings can also indicate an increased susceptibility to hospital admission for infections among children who will later develop nonaffective psychosis due to social or familial/genetic factors.
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Details
- Title
- Hospital admission with infection during childhood and risk for psychotic illness--a population-based cohort study
- Creators
- Åsa Blomström - Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden; asa.blomstrom@ki.seHåkan Karlsson - Department of Neuroscience, Karolinska Institutet, Stockholm, SwedenAnna Svensson - Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenThomas Frisell - Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, SwedenBrian K Lee - Department of Epidemiology and Biostatistics, Drexel University School of Public Health, PhiladelphiaHenrik Dal - Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenCecilia Magnusson - Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenChristina Dalman - Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
- Publication Details
- Schizophrenia bulletin, v 40(6), pp 1518-1525
- Publisher
- Oxford University Press; United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000344611900036
- Scopus ID
- 2-s2.0-84913592000
- Other Identifier
- 991014877700404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry