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Journal article
Host-Biomaterial Interactions in Zebrafish
ACS biomaterials science & engineering, v 4(4), pp 1233-1240
01 Apr 2018
PMID: 33418656
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Host biomaterial interactions are critical determinants of the success or failure of an implant. However, detailed understanding of this process is limited due to a lack of dynamic tools for in vivo analyses. Here we characterize host biomaterial interactions in zebrafish (Danio rerio), which are optically translucent and genetically tractable. Histological and immunohistochemical analyses following polypropylene suture implantation into adult zebrafish showed prolonged elevation of immune cell recruitment and collagen deposition, resembling a foreign body response. Live in vivo analysis showed that adsorption of the immunomodulatory cytokine interleukin-10 to a polystyrene micropartide, microinjected into transgenic larval zebrafish, inhibited neutrophil recruitment after 24 h compared to control micropartides, with no change in macrophage recruitment. This study illustrates that zebrafish are useful to investigate host biomaterial interactions and have potential for high-throughput analysis of novel immunomodulatory biomaterials.
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Details
- Title
- Host-Biomaterial Interactions in Zebrafish
- Creators
- Claire E. Witherel - Drexel UniversityDavid Gurevich - School of BiochemistryJohn D. Collin - Bristol Royal InfirmaryPaul Martin - Fundamental BioscienceKara L. Spiller - Bristol Royal Infirmary
- Publication Details
- ACS biomaterials science & engineering, v 4(4), pp 1233-1240
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 15
- Grant note
- HL130037 / NHLBI RIM WT097791/Z/11/Z / Wellcome Trust Investigator Award; Wellcome Trust Whitaker International Fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000429886800011
- Scopus ID
- 2-s2.0-85045205067
- Other Identifier
- 991019168032304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials