Journal article
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium
Scientific reports, v 14(1), 11798
23 May 2024
PMID: 38782975
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Using pooled vaginal microbiota data from pregnancy cohorts (N = 683 participants) in the Environmental influences on Child Health Outcomes (ECHO) Program, we analyzed 16S rRNA gene amplicon sequences to identify clinical and demographic host factors that associate with vaginal microbiota structure in pregnancy both within and across diverse cohorts. Using PERMANOVA models, we assessed factors associated with vaginal community structure in pregnancy, examined whether host factors were conserved across populations, and tested the independent and combined effects of host factors on vaginal community state types (CSTs) using multinomial logistic regression models. Demographic and social factors explained a larger amount of variation in the vaginal microbiome in pregnancy than clinical factors. After adjustment, lower education, rather than self-identified race, remained a robust predictor of L. iners dominant (CST III) and diverse (CST IV) (OR = 8.44, 95% CI = 4.06-17.6 and OR = 4.18, 95% CI = 1.88-9.26, respectively). In random forest models, we identified specific taxonomic features of host factors, particularly urogenital pathogens associated with pregnancy complications (Aerococcus christensenii and Gardnerella spp.) among other facultative anaerobes and key markers of community instability (L. iners). Sociodemographic factors were robustly associated with vaginal microbiota structure in pregnancy and should be considered as sources of variation in human microbiome studies.
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Details
- Title
- Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium
- Creators
- Kimberly McKee - University of MichiganChristine M. Bassis - University of MichiganJonathan Golob - University of MichiganBeatrice Palazzolo - University of MichiganAnanda Sen - University of MichiganSarah S. Comstock - Michigan State UniversityChristian Rosas-Salazar - Vanderbilt University Medical CenterJoseph B. Stanford - University of UtahThomas O'Connor - University of RochesterJames E. Gern - University of Wisconsin–MadisonNigel Paneth - Michigan State UniversityAnne L. Dunlop - Emory University
- Publication Details
- Scientific reports, v 14(1), 11798
- Publisher
- Nature Publishing
- Number of pages
- 19
- Grant note
- UH3OD023289; UH3OD023282; UH3OD023287; UH3OD023244; UH3OD023275; UH3OD023271; UH3OD023347; UH3OD023389; UH3OD023288; UH3OD023349; UH3OD023285; UH3OD023290; UH3OD023272; UH3OD023249; UH3OD023305; UH3OD023337 / 'Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health' U2COD023375; U24OD023382; U24OD023319; UH3OD023251; UH3OD023320; UH3OD023253; UH3OD023248; UH3OD023313; UH3OD023328; UH3OD023318; UH3OD023279 / Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001230489600035
- Scopus ID
- 2-s2.0-85194130720
- Other Identifier
- 991022202101904721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Microbiology