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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Host genetic determinants of the gut microbiota of wild mice
Molecular ecology, v 28(13), pp 3197-3207
Jul 2019
PMCID: 6660988
PMID: 31141224
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Identifying a common set of genes that mediate host-microbial interactions across populations and species of mammals has broad relevance for human health and animal biology. However, the genetic basis of the gut microbial composition in natural populations remains largely unknown outside of humans. Here, we used wild house mouse populations as a model system to ask three major questions: (a) Does host genetic relatedness explain interindividual variation in gut microbial composition? (b) Do population differences in the microbiota persist in a common environment? (c) What are the host genes associated with microbial richness and the relative abundance of bacterial genera? We found that host genetic distance is a strong predictor of the gut microbial composition as characterized by 16S amplicon sequencing. Using a common garden approach, we then identified differences in microbial composition between populations that persisted in a shared laboratory environment. Finally, we used exome sequencing to associate host genetic variants with microbial diversity and relative abundance of microbial taxa in wild mice. We identified 20 genes that were associated with microbial diversity or abundance including a macrophage-derived cytokine (IL12a) that contained three nonsynonymous mutations. Surprisingly, we found a significant overrepresentation of candidate genes that were previously associated with microbial measurements in humans. The homologous genes that overlapped between wild mice and humans included genes that have been associated with traits related to host immunity and obesity in humans. Gene-bacteria associations identified in both humans and wild mice suggest some commonality to the host genetic determinants of gut microbial composition across mammals.
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Details
- Title
- Host genetic determinants of the gut microbiota of wild mice
- Creators
- Taichi A. Suzuk - Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USAMegan Phifer-Rixey - Monmouth UniversityKatya L. Mack - Museum of Vertebrate ZoologyMichael J. Sheehan - Cornell UniversityDana Lin - Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USAKe Bi - QB3Michael W. Nachman - Museum of Vertebrate Zoology
- Publication Details
- Molecular ecology, v 28(13), pp 3197-3207
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- R01 GM127468; R01 GM074245 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01GM127468 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000477750800006
- Scopus ID
- 2-s2.0-85067388127
- Other Identifier
- 991021229903504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Ecology
- Evolutionary Biology