Journal article
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Nature communications, v 16(1), 586
10 Jan 2025
PMID: 39794319
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls. We find that transplant recipients have higher nasal SARS-CoV-2 viral abundance and impaired viral clearance, and lower anti-spike IgG levels. In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood and nasal transcriptional profiling demonstrate unexpected upregulation of innate immune signaling pathways and increased levels of several proinflammatory serum chemokines. Severe disease in transplant recipients, however, is characterized by a less robust induction of pro-inflammatory genes and chemokines. Together, our study reveals distinct immune features and altered viral dynamics in solid organ transplant recipients.
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Details
- Title
- Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
- Creators
- Harry Pickering - University of California, Los AngelesJoanna Schaenman - University of California, Los AngelesHoang Van Phan - University of California, San FranciscoCole Maguire - The University of Texas at AustinAlexandra Tsitsiklis - University of California, San FranciscoNadine Rouphael - Emory UniversityNelson Iván Agudelo Higuita - OU HealthMark A Atkinson - University of FloridaScott Brakenridge - University of FloridaMonica Fung - University of California, San FranciscoWilliam Messer - Oregon Health & Science UniversityRamin Salehi-Rad - University of California, Los AngelesMatthew C Altman - Emory UniversityPatrice M Becker - National Institutes of HealthSteven E Bosinger - Boston Children's HospitalWalter Eckalbar - University of California, San FranciscoAnnmarie Hoch - Boston Children's HospitalNaresh Doni Jayavelu - University of WashingtonSeunghee Kim-Schulze - Icahn School of Medicine at Mount SinaiMeagan Jenkins - University of California, Los AngelesSteven H Kleinstein - Palo Alto UniversityFlorian Krammer - Broad InstituteHolden T Maecker - Stanford UniversityAl Ozonoff - Boston Children's HospitalJoann Diray-Arce - Brigham and Women's HospitalAlbert Shaw - Yale UniversityLindsey Baden - Brigham and Women's HospitalOfer Levy - Broad InstituteElaine F Reed - University of California, Los AngelesCharles R Langelier - University of California, San FranciscoIMPACC Network
- Publication Details
- Nature communications, v 16(1), 586
- Publisher
- Nature Publishing
- Grant note
- U19 AI077439 / NIAID NIH HHS U19 AI089992 / NIAID NIH HHS U54 AI142766 / NIAID NIH HHS I01 BX005023 / BLRD VA U19 AI125357 / NIAID NIH HHS U19 AI057229 / NIAID NIH HHS U19 AI062629 / NIAID NIH HHS R01 AI135803 / NIAID NIH HHS U19 AI090023 / NIAID NIH HHS P01 AI153559 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001410295300001
- Scopus ID
- 2-s2.0-85215351003
- Other Identifier
- 991022197421404721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Transplantation