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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Household air pollution and blood markers of inflammation: A cross-sectional analysis
Indoor air, v 31(5), pp 1509-1521
01 Sep 2021
PMID: 33749948
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1 beta, and TNF-alpha) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM2.5), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO2) in a subset of 97 participants. We conducted an exposure-response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM2.5. As expected, kitchen area BC concentrations were positively associated with TNF-alpha (pro-inflammatory) concentrations and negatively associated with IL-10, an anti-inflammatory marker, controlling for confounders in single- and multi-pollutant models. However, contrary to expectations, kitchen area BC and NO2 concentrations were negatively associated with IL-1 beta, a pro-inflammatory marker. No associations were identified for IL-6 or CRP, or for any marker in relation to personal exposures.
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Details
- Title
- Household air pollution and blood markers of inflammation: A cross-sectional analysis
- Creators
- Magdalena Fandino-Del-Rio - BloombergJosiah L. Kephart - BloombergKendra N. Williams - Johns Hopkins MedicineGary Malpartida - Cayetano Heredia UniversityDana Boyd Barr - Emory Univ, Rollins Sch Publ Hlth, Gangarosa Dept Environm Hlth, Atlanta, GA 30322 USAKyle Steenland - Emory UniversityKirsten Koehler - BloombergWilliam Checkley - Johns Hopkins Medicine
- Publication Details
- Indoor air, v 31(5), pp 1509-1521
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- UNF-16-810 / Clean Cooking Alliance of the United Nations Foundation Global Environmental and Occupational Health (GEOHealth) D43TW009340 / United States National Institutes of Health Research Training Grant - United States National Institutes of Health through National Institute of Mental Health P30ES019776 / HERCULES Exposome Research Center Centre for Global Health at Johns Hopkins University United States National Institutes of Health through National Institute of Environmental Health Sciences COPD Discovery Award from Johns Hopkins University United States National Institutes of Health through Fogarty International Center Fogarty International Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC) D43TW009340 / United States National Institutes of Health Research Training Grant - United States National Institutes of Health through National Institute of Neurological Disorders and Stroke D43TW009340 / United States National Institutes of Health Research Training Grant - United States National Institutes of Health through National Heart, Lung, and Blood Institute David Leslie Swift Fund of the Bloomberg School of Public Health, Johns Hopkins University D43TW009340 / United States National Institutes of Health Research Training Grant - United States National Institutes of Health through Fogarty International Center T32HL007534 / National Heart, Lung, And Blood Institute of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) D43TW009340 / United States National Institutes of Health Research Training Grant - United States National Institutes of Health through National Institute of Environmental Health Sciences United States National Institutes of Health through National Cancer Institute U01TW010107; U2RTW010114 / United States National Institutes of Health through Centers for Disease Control T32ES007141 / National Institute of Environmental Health Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000631672400001
- Scopus ID
- 2-s2.0-85102798217
- Other Identifier
- 991019174096204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Construction & Building Technology
- Engineering, Environmental
- Public, Environmental & Occupational Health