Journal article
Household endotoxin levels and the risk of non-Hodgkin lymphoma
Cancer causes & control, v 24(2), pp 357-364
01 Feb 2013
PMID: 23277417
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha). Because TNF-alpha polymorphisms that increase TNF-alpha production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that increased levels of household endotoxin would be associated with an increased NHL risk.
We evaluated this association in the National Cancer Institute/Surveillance, Epidemiology and End Results (NCI/SEER) NHL multicenter population-based case-control study. Used vacuum cleaner bags were collected from participants during a home interview. Dust samples from the bags of 594 cases and 442 controls were analyzed for endotoxin [endotoxin unit (EU)/mg of dust] using the kinetic chromogenic Limulus amebocyte lysate assay. Multivariable logistic regression was used to estimate the effect of endotoxin on NHL risk adjusted for age, sex, race, education, study center, and farm exposure.
Endotoxin was not associated with NHL overall [odds ratio (OR) for highest quartile of endotoxin levels = 0.81, 95 % confidence interval (CI) = 0.55, 1.20; p for trend = 0.35] or with diffuse large B-cell lymphoma (OR = 0.63, 95 % CI = 0.34, 1.16; p = 0.31) or follicular lymphoma (OR = 1.07, 95 % CI = 0.61, 1.89; p = 0.73) subtypes. Both working and living on a farm were associated with higher household endotoxin levels compared to never working (p = 0.009) or living (p = 0.01) on a farm. Excluding farmers from the analysis did not change the results.
We found no evidence of a role for household endotoxin in NHL etiology.
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Details
- Title
- Household endotoxin levels and the risk of non-Hodgkin lymphoma
- Creators
- Jun Wang - University of Southern CaliforniaWendy Cozen - University of Southern CaliforniaPeter S. Thorne - University of IowaKiros Berhane - University of Southern CaliforniaJames R. Cerhan - College Station Medical CenterPatricia Hartge - National Institutes of HealthMary H. Ward - National Institutes of HealthAnneclaire J. De Roos - University of WashingtonRichard K. Severson - Wayne State UniversityLindsay M. Morton - National Institutes of HealthLeslie Bernstein - University of Southern CaliforniaMartha S. Linet - National Institutes of HealthJoanne S. Colt - National Institutes of Health
- Publication Details
- Cancer causes & control, v 24(2), pp 357-364
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- P30 CA014089 / Norris Comprehensive Cancer Center Support Grant National Cancer Institute Division of Cancer Epidemiology and Genetics; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology & Genetics P30ES007048 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01PC067009 / DIVISION OF CANCER CONTROL &POPULATION SCIENCE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH National Cancer Institute- Division of Cancer Control & Population Sciences P30 ES005605 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01-PC-35139; N01 PC065064; NO1-PC-67008; N01-PC-71105; N01-PC67009 / Surveillance, Epidemiology and End Results Program National Cancer Institute from the National Institutes of Health U55/CCR921930-02 / Centers for Disease Control and Prevention's National Program of Cancer Registries; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA P30CA014089 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) University of Washington Wayne State University Mayo Clinic 103885 / California Department of Health Services
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000314063900017
- Scopus ID
- 2-s2.0-84878886097
- Other Identifier
- 991020099635104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health