Journal article
How Biologics Have Changed the Drug Discovery Landscape
Annual review of pharmacology and toxicology, v 65(1), pp 29-46
10 Oct 2024
PMID: 39389098
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Advances in molecular biology and molecular genetics as well as major scientific breakthroughs in immunology and oncology have led to the rapid growth of biologic therapeutics. Their success has resulted in significant changes to virtually every step in the drug discovery and development process. Biologics are produced by living organisms, and screening libraries are generated by immunization or phage display. Lead optimization utilizes sophisticated protein engineering to improve drug-like properties and targeting specificity. The manufacturing process for biologics is complex and requires highly specialized facilities. Determination of pharmacology and safety must overcome the complications associated with species specificity. Initial clinical testing must proceed more slowly and carefully due to the limited predictive utility of preclinical data. In summary, the drug discovery and development process has been dramatically altered by biologic therapeutics and will continue to evolve with the introduction of messenger RNA-based therapeutics and the application of artificial intelligence.
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Details
- Title
- How Biologics Have Changed the Drug Discovery Landscape
- Creators
- Paul McGonigle - Drexel University, Pharmacology and Physiology
- Publication Details
- Annual review of pharmacology and toxicology, v 65(1), pp 29-46
- Publisher
- ANNUAL REVIEWS
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:001410738300003
- Scopus ID
- 2-s2.0-85216715712
- Other Identifier
- 991021916518704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy
- Toxicology