Journal article
How spinalized rats can walk: biomechanics, cortex, and hindlimb muscle scaling--implications for rehabilitation
Annals of the New York Academy of Sciences, v 1198(1)
Jun 2010
PMID: 20536943
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neonatal spinalized (NST) rats can achieve autonomous weight-supported locomotion never seen after adult injury. Mechanisms that support function in NST rats include increased importance of cortical trunk control and altered biomechanical control strategies for stance and locomotion. Hindlimbs are isolated from perturbations in quiet stance and act in opposition to forelimbs in locomotion in NST rats. Control of roll and yaw of the hindlimbs is crucial in their locomotion. The biomechanics of the hind limbs of NST rats are also likely crucial. We present new data showing the whole leg musculature scales proportional to normal rat musculature in NST rats, regardless of function. This scaling is a prerequisite for the NST rats to most effectively use pattern generation mechanisms and motor patterns that are similar to those present in intact rats. Pattern generation may be built into the lumbar spinal cord by evolution and matched to the limb biomechanics, so preserved muscle scaling may be essential to the NST function observed.
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Details
- Title
- How spinalized rats can walk: biomechanics, cortex, and hindlimb muscle scaling--implications for rehabilitation
- Creators
- Simon F Giszter - Neurobiology and Anatomy, School of Bioengineering, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. sgiszter@drexelmed.eduGreg HockensmithArun RamakrishnanUbong Ime Udoekwere
- Publication Details
- Annals of the New York Academy of Sciences, v 1198(1)
- Publisher
- Wiley; United States
- Grant note
- P50 NS024707 / NINDS NIH HHS NS44564 / NINDS NIH HHS R01 NS054894 / NINDS NIH HHS NS54894 / NINDS NIH HHS R01 NS054894-03 / NINDS NIH HHS R01 NS072651 / NINDS NIH HHS R01 NS040412 / NINDS NIH HHS NS24707 / NINDS NIH HHS R01 NS044564 / NINDS NIH HHS R01 NS054894-02 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Nursing and Health Professions
- Web of Science ID
- WOS:000281413900029
- Scopus ID
- 2-s2.0-77954574722
- Other Identifier
- 991014878229704721
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- Web of Science research areas
- Neurosciences