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How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow”
Journal article   Open access   Peer reviewed

How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow”

Leif D. Nelin and Vineet Bhandari
F1000 research, v 6, pp 539-539
21 Apr 2017
PMID: 28503300
url
https://doi.org/10.12688/f1000research.10832.1View
Published, Version of Record (VoR)CC BY V4.0 Open

Abstract

BPD bronchopulmonary dysplasia neonatal intensive care Review
Bronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in persistent inflammation, culminating in the characteristic pulmonary phenotype of BPD of impaired alveolarization and dysregulated vascularization. In this article, we highlight specific areas in current management, and speculate on therapeutic strategies that are on the horizon, that we believe will make an impact in decreasing the incidence of BPD in your neonatal intensive care units.

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