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Abstract
BPD bronchopulmonary dysplasia neonatal intensive care Review
Bronchopulmonary dysplasia, or BPD, is the most common chronic lung disease in infants. Genetic predisposition and developmental vulnerability secondary to antenatal and postnatal infections, compounded with exposure to hyperoxia and invasive mechanical ventilation to an immature lung, result in persistent inflammation, culminating in the characteristic pulmonary phenotype of BPD of impaired alveolarization and dysregulated vascularization. In this article, we highlight specific areas in current management, and speculate on therapeutic strategies that are on the horizon, that we believe will make an impact in decreasing the incidence of BPD in your neonatal intensive care units.
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Details
Title
How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow”
Creators
Leif D. Nelin - The Ohio State University
Vineet Bhandari - St. Christopher's Hospital for Children