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Journal article
HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model
The journals of gerontology. Series A, Biological sciences and medical sciences, v 77(2), pp 268-275
03 Feb 2022
PMID: 34610126
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To explore the role of the small heat shock protein beta 1 (HspB1, also known as Hsp25 in rodents and Hsp27 in humans) in longevity, we created a Caenorhabiditis elegans model with a high level of ubiquitous expression of the naked mole-rat HspB1 protein. The worms showed increased life span under multiple conditions and also increased resistance to heat stress. RNAi experiments suggest that HspB1-induced life extension is dependent on the transcription factors skn-1 (Nrf2) and hsf-1 (Hsf1). RNAseq from HspB1 worms showed an enrichment in several skn-1 target genes, including collagen proteins and lysosomal genes. Expression of HspB1 also improved functional outcomes regulated by SKN-1, specifically oxidative stress resistance and pharyngeal integrity. This work is the first to link a small heat shock protein with collagen function, suggesting a novel role for HspB1 as a hub between canonical heat response signaling and SKN-1 transcription.
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Details
- Title
- HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model
- Creators
- Courtney Carroll Alexander - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.Erin Munkáscy - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.Haven Tillmon - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.Tamara Fraker - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.Jessica Scheirer - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.Deborah Holstein - Department of Cell Systems and Anatomy, UTHSCSA.Damian Lozano - Department of Cell Systems and Anatomy, UTHSCSA.Maruf Khan - Department of Cell Systems and Anatomy, UTHSCSA.Tali Gidalevitz - Drexel UniversityJames D Lechleiter - Department of Cell Systems and Anatomy, UTHSCSA.Alfred L Fisher - University of Nebraska Medical CenterHabil Zare - Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UTHSCSA, San Antonio, TX.Karl A Rodriguez - Sam and Ann Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center San Antonio (UTHSCSA), San Antonio, TX.
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, v 77(2), pp 268-275
- Publisher
- Oxford University Press
- Grant note
- K12 GM111726 / NIH HHS K12 GM111726 / NIGMS NIH HHS P40 OD010440 / NIH HHS R00 AG049940 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000755209900020
- Scopus ID
- 2-s2.0-85120415837
- Other Identifier
- 991019167445904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Gerontology