Journal article
Human Circulating PD-1(+)CXCR3(-)CXCR5(+) Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
Immunity (Cambridge, Mass.), v 39(4), pp 758-769
17 Oct 2013
PMID: 24035365
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an antibody-dependent HIV vaccine might be possible, given the discovery of HIV broadly neutralizing antibodies (bnAbs) in some HIV-infected individuals. However, these antibodies are difficult to develop and have characteristics indicative of a high degree of affinity maturation in germinal centers (GCs). CD4(+) T follicular helper (Tfh) cells are specialized for B cell help and necessary for GCs. Therefore, the development of HIV bnAbs might depend on Tfh cells. Here, we identified in normal individuals a subpopulation of circulating memory PD-1(+)CXCR5(+) CD4(+) T cells that are resting memory cells most related to bona fide GC Tfh cells by gene expression profile, cytokine profile, and functional properties. Importantly, the frequency of these cells correlated with the development of bnAbs against HIV in a large cohort of HIV+ individuals.
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Details
- Title
- Human Circulating PD-1(+)CXCR3(-)CXCR5(+) Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
- Creators
- Michela Locci - La Jolla Institute for ImmunologyColin Havenar-Daughton - University of California San DiegoElise Landais - International AIDS Vaccine InitiativeJennifer Wu - La Jolla Institute for ImmunologyMark A. Kroenke - La Jolla Institute for ImmunologyCecilia L. Arlehamn - La Jolla Inst Allergy & Immunol, Div Vaccine Discovery, La Jolla, CA 92037 USALaura F. Su - Howard Hughes Medical InstituteRafael Cubas - Vaccine & Gene Therapy Institute of FloridaMark M. Davis - Howard Hughes Medical InstituteAlessandro Sette - La Jolla Institute for ImmunologyElias K. Haddad - Vaccine & Gene Therapy Institute of FloridaPascal Poignard - Scripps Research InstituteShane Crotty - University of California San Diego
- Publication Details
- Immunity (Cambridge, Mass.), v 39(4), pp 758-769
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- S10RR027366 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) AI090970 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) IAVI UM1-AI10066 / CHAVI-ID UM1AI100663 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:000330950000016
- Scopus ID
- 2-s2.0-84885743368
- Other Identifier
- 991020100186904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology