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Journal article
Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation
Biomedicines, v 10(2)
01 Feb 2022
PMID: 35203464
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mesenchymal stromal cells (MSCs) have unique immunomodulatory capacities. We investigated hair follicle-derived MSCs (HF-MSCs) from the dermal sheath, which are advantageous as an alternative source because of their relatively painless and minimally risky extraction procedure. These cells expressed neural markers upon isolation and maintained stemness for a minimum of 10 passages. Furthermore, HF-MSCs showed responsiveness to pro-inflammatory environments by expressing type-II major histocompatibility complex antigens (MHC)-II to a lesser extent than adipose tissue-derived MSCs (AT-MSCs). HF-MSCs effectively inhibited the proliferation of peripheral blood mononuclear cells equivalently to AT-MSCs. Additionally, HF-MSCs promoted the induction of CD4+CD25+FOXP3+ regulatory T cells to the same extent as AT-MSCs. Finally, HF-MSCs, more so than AT-MSCs, skewed M0 and M1 macrophages towards M2 phenotypes, with upregulation of typical M2 markers CD163 and CD206 and downregulation of M1 markers such as CD64, CD86, and MHC-II. Thus, we conclude that HF-MSCs are a promising source for immunomodulation.
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Details
- Title
- Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation
- Creators
- Beatriz Hernaez-Estrada - Drexel UniversityAinhoa Gonzalez-Pujana - Bioaraba, NanoBioCel Research Group, 01006 Vitoria-Gasteiz, SpainAndoni Cuevas - Clínica RementeríaAnder Izeta - TecnunKara L. L. Spiller - Drexel UniversityManoli Igartua - Bioaraba, NanoBioCel Research Group, 01006 Vitoria-Gasteiz, SpainEdorta Santos-Vizcaino - Bioaraba, NanoBioCel Research Group, 01006 Vitoria-Gasteiz, SpainRosa Maria Hernandez - Bioaraba, NanoBioCel Research Group, 01006 Vitoria-Gasteiz, Spain
- Publication Details
- Biomedicines, v 10(2)
- Publisher
- Mdpi
- Number of pages
- 19
- Grant note
- IT907-16 / Eusko Jaurlaritza SAF2017-82292-R / MINECO; Spanish Government MCIU-AEI/FEDER, UE U10 / ICTS "NANBIOSIS" Drug Formulation Unit
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000770695100001
- Scopus ID
- 2-s2.0-85123644533
- Other Identifier
- 991019169243604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Medicine, Research & Experimental
- Pharmacology & Pharmacy