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Human Immunodeficiency Virus Type 1 Cellular Entry and Exit in the T Lymphocytic and Monocytic Compartments: Mechanisms and Target Opportunities During Viral Disease
Journal article   Peer reviewed

Human Immunodeficiency Virus Type 1 Cellular Entry and Exit in the T Lymphocytic and Monocytic Compartments: Mechanisms and Target Opportunities During Viral Disease

Benjamas Aiamkitsumrit, Neil T Sullivan, Michael R Nonnemacher, Vanessa Pirrone and Brian Wigdahl
Advances in virus research, v 93, pp 257-311
2015
DOI: https://doi.org/10.1016/bs.aivir.2015.04.001
PMID: 26111588
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals CD4-Positive T-Lymphocytes - virology HIV Infections - virology HIV-1 - genetics HIV-1 - physiology Humans Monocytes - virology Virus Internalization Virus Release
During the course of human immunodeficiency virus type 1 infection, a number of cell types throughout the body are infected, with the majority of cells representing CD4+ T cells and cells of the monocyte-macrophage lineage. Both types of cells express, to varying levels, the primary receptor molecule, CD4, as well as one or both of the coreceptors, CXCR4 and CCR5. Viral tropism is determined by both the coreceptor utilized for entry and the cell type infected. Although a single virus may have the capacity to infect both a CD4+ T cell and a cell of the monocyte-macrophage lineage, the mechanisms involved in both the entry of the virus into the cell and the viral egress from the cell during budding and viral release differ depending on the cell type. These host-virus interactions and processes can result in the differential targeting of different cell types by selected viral quasispecies and the overall amount of infectious virus released into the extracellular environment or by direct cell-to-cell spread of viral infectivity. This review covers the major steps of virus entry and egress with emphasis on the parts of the replication process that lead to differences in how the virus enters, replicates, and buds from different cellular compartments, such as CD4+ T cells and cells of the monocyte-macrophage lineage.

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12 citations in Web of Science
12 citations in Scopus

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Web of Science research areas
Virology
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