Journal article
Human Melanoma Cells Adhesion on the Surface of Polymeric Chemoattractants
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(4-6), pp.932-938
01 Dec 2008
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Abstract
Two dimensional(2-D) polymeric matrices with free radical generating quinoid compounds, hydroquinone-grafted-polypropylene(HQ-g-PP) and vitamin-K-1-grafted-polypropylene(VK1-g-PP), were prepared by a liquid phase photo-grafting technique, and the adhesion of primary(WM 793) and metastatic(WM 1205) human melanoma cells to prepared surfaces was investigated. Grafting of polar groups in VK(1)and HQ increased surface tension of PP matrices from 27 dyne/cm to 39 dyne/cm, resulting in decreased protein adsorption. In addition, electron paramagnetic resonance(EPR) spectra showed that the matrices generated free radicals at the interface when in contact with serum. Both WM 793 and WM 1205 cells showed an enhanced adhesion to the prepared samples compared to the control PP. The adhesion of metastatic melanoma cells onto the polymeric matrices was more pronounced than that of primary melanoma cells. VK1-g-PP with twice as many free radical generating groups in a unit graft yield as HQ-g-PP had a greater cell adhesion. The number of cells adhered to the surface of the polymeric chemoattractants increases with increase in the content of free radicals at the interface.
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Details
- Title
- Human Melanoma Cells Adhesion on the Surface of Polymeric Chemoattractants
- Creators
- Kyu Nam Park - Catholic Univ, Coll Med, Inst Cell & Tissue Engi, Seoul 137701, South KoreaHan Joon Kim - Catholic Univ, Coll Med, Dept Emergency, Seoul 137701, South KoreaJung Hee Wee - Catholic Univ, Coll Med, Dept Emergency, Seoul 137701, South KoreaWho Kyong Lee - Catholic Univ, Coll Med, Dept Obstet & Gynecol, Seoul 137701, South KoreaHeung Jae Chun - Catholic Univ, Coll Med, Inst Cell & Tissue Engi, Seoul 137701, South KoreaJu Woong Jang - Korea Bone Bank Co Ltd, Res Inst Biomed Eng, Seoul 153782, South KoreaAnthony Addison - Sci & Hlth Syst Drexel Univ, Sch Biomed Eng, Philadelphia, PA 19104 USARichard B. Beard - Sci & Hlth Syst Drexel Univ, Sch Biomed Eng, Philadelphia, PA 19104 USA
- Publication Details
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.5(4-6), pp.932-938
- Publisher
- Korean Tissue Engineering Regenerative Medicine Soc
- Number of pages
- 7
- Grant note
- 10030022 / Ministry of Knowledge Economy of Korea; Ministry of Knowledge Economy, Republic of Korea
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Identifiers
- 991019170453704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell & Tissue Engineering
- Engineering, Biomedical