Journal article
Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern
Journal of neurovirology, v 25(3)
01 Jun 2019
PMID: 30693421
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human T cell leukemia virus type 1 (HTLV-1) and Zika virus (ZIKV) have been considered neglected viruses of low public health concern until recently when incidences of HTLV-1 and ZIKV were observed to be linked to serious immune-related disease and neurological complications. This review will discuss the epidemiology, genomic evolution, virus-host interactions, virulence factors, neuropathological sequelae, and current perspectives of these reemerging viruses. There are no FDA-approved therapeutics or vaccines against these viruses, and as such, it is important for clinical trials to focus on developing vaccines that can induce cell-mediated immune response to confer long-term protective immunity. Furthermore, attention should be paid to reducing the transmission of these viruses through unprotected sex, infected blood during sharing of contaminated needles, donated blood and organs, and vertical transmission from mother to baby via breastfeeding. There is an urgent need to re-evaluate repurposing current antiviral therapies as well as developing novel antiviral agents with enhanced efficacy due to the high morbidity rate associated with these two reemerging chronic viral diseases.
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Details
- Title
- Human T cell leukemia virus type 1 and Zika virus: tale of two reemerging viruses with neuropathological sequelae of public health concern
- Creators
- DeGaulle I. Chigbu - Drexel University, Microbiology and ImmunologyPooja Jain - Drexel UniversityBrenndan L. Crumley - Drexel University, Microbiology and ImmunologyDip Patel - Drexel University, Microbiology and ImmunologyZafar K. Khan - Drexel University
- Publication Details
- Journal of neurovirology, v 25(3)
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- R01CA054559-20 / NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS097147 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 1R01NS097147-01A1 / NINDS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000475688500001
- Scopus ID
- 2-s2.0-85061049874
- Other Identifier
- 991019167858504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Virology