Journal article
Human antibody repertoire among kidney donors with and without HIV
JCI insight, e203645
12 Mar 2026
PMID: 41817597
Featured in Collection : Drexel's Newest Publications
Abstract
BACKGROUND. Transplanting kidneys from donors with HIV to recipients with HIV has become standard clinical practice. However, donors with HIV may have higher prevalence of viral and bacterial infections and autoimmunity that could increase allograft rejection in recipients.
METHODS. We included deceased kidney donors (60 with HIV and 41 without HIV) who participated in a multicenter prospective study of HIV kidney transplantation between April 2018-September 2021. Using Phage ImmunoPrecipitation Sequencing, we compared the human antibody repertoire (allergens, autoantibodies, viruses and bacterial toxins) between donors with and without HIV, and evaluated their association with recipient allograft rejection. Moderated t-tests were used to assess reactivity and a multivariate logistic regression model adjusted for donor sex and KDPI assessed the association between donor adenovirus reactivity and recipient allograft rejection.
RESULTS. Compared to donors without HIV, donors with HIV had lower BMI and were more likely to be African American. The median number of positive autoantibodies was marginally higher among donors with HIV (499 [IQR = 357, 579]) compared to donors without HIV (395 [IQR = 256, 538] (P = 0.058). Donors with HIV additionally had significantly higher antibody reactivity to Epstein-Barr virus and cytomegalovirus (q < 0.05). Among all donors with and without HIV, antibodies to adenovirus were significantly associated with increased rejection among recipients, including after adjusting for false discovery (q < 0.05) and also adjusting for demographic factors using multivariable logistic regression (odds ratio = 4.97, 95% CI = 1.89–13.61).
CONCLUSION. The presence of antibodies to adenovirus infection in kidney donors with HIV may be associated with allograft rejection.
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Details
- Title
- Human antibody repertoire among kidney donors with and without HIV
- Creators
- Xianming Zhu - Johns Hopkins UniversityWilliam Morgenlander - Johns Hopkins UniversityDiane Brown - Johns Hopkins UniversityYolanda Eby - Johns Hopkins UniversityMegan Morsheimer - National Institute of Allergy and Infectious DiseasesJonah Odim - National Institute of Allergy and Infectious DiseasesSerena Bagnasco - Johns Hopkins UniversityMeenakshi M. Rana - Icahn School of Medicine at Mount SinaiSander Florman - Mount Sinai HospitalRachel Friedman-Moraco - Emory UniversityPeter Stock - University of California, San FranciscoAlexander Gilbert - Georgetown UniversityShikha Mehta - University of Alabama at BirminghamValentina Stosor - Northwestern UniversitySapna A. Mehta - NYU Langone HealthMarcus Pereira - Columbia University Irving Medical CenterCatherine Butkus‐Small - Weill Cornell MedicineMichele I Morris - University of Miami HospitalJonathan Hand - Ochsner Health SystemSaima Aslam - University of California San DiegoGhady Haidar - University of PittsburghMaricar Malinis - Yale UniversityCarlos A.Q. Santos - Rush University Medical CenterJoanna Schaenmann - David Geffen School of Medicine at UCLADavid Wojciechowski - The University of Texas Southwestern Medical CenterKarthik M Ranganna - Drexel University, Medicine (Graduate)Emily A. Blumberg - University of PennsylvaniaNahel Elias - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaJose A Castillo-Lugo - Clinical Research InstituteEmmanouil Giorgakis - University of Arkansas for Medical SciencesSenu Apewokin - University of CincinnatiM. Kate Grabowski - Johns Hopkins UniversityDorry L Segev - New York UniversityAndrew D. Redd - National Institute of Allergy and Infectious DiseasesChristine M. Durand - Johns Hopkins UniversityH Benjamin Larman - Johns Hopkins UniversityAaron A A Tobian - Johns Hopkins University School of Medicine
- Publication Details
- JCI insight, e203645
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Other Identifier
- 991022165638404721