Journal article
Human cholecystokinin-A receptor is not an oncofetal protein
Digestive diseases and sciences, v 45(3), pp 538-543
01 Mar 2000
PMID: 10749330
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors in human fetal, postnatal, and adult pancreas to determine whether the appearance of CCK-A receptors in pancreatic adenocarcinomas reflected oncofetal antigen or pancreatic neoantigen expression. Messenger ribonucleic acid (mRNA) was isolated from six paraffin-embedded normal pancreatic autopsy specimens ranging in age from 17 weeks postfertilization through 26 days following full-term delivery, and samples of adult human tissues, including pancreas and pancreatic adenocarcinoma. Using reverse transcription-polymerase chain reactions, CCK-B receptor mRNA was expressed in all specimens of normal fetal and postnatal human pancreas, adult pancreas, and pancreatic adenocarcinomas. CCK-A receptor mRNA was selectively expressed only in pancreatic adenocarcinomas. These data suggest that selective CCK-A receptor expression in pancreatic adenocarcinomas reflects neoantigen expression in humans.
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Details
- Title
- Human cholecystokinin-A receptor is not an oncofetal protein
- Creators
- David Weinberg - Thomas Jefferson UniversityChi So - Allegheny University of the Health SciencesBruce Ruggeri - Allegheny University of the Health SciencesSanjoy Biswas - Thomas Jefferson UniversitySaumitra Biswas - Pediatrics
- Publication Details
- Digestive diseases and sciences, v 45(3), pp 538-543
- Publisher
- Springer Nature B.V
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000086153600015
- Scopus ID
- 2-s2.0-0034023335
- Other Identifier
- 991019167975504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology