Journal article
Human herpesvirus evasion of humoral immunity and implications for vaccine development
Nature reviews. Microbiology
13 Mar 2026
PMID: 41826436
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Herpesviruses are highly species-specific, having co-evolved with their respective hosts over millennia. This evolutionary relationship has led to the development of highly specialized immune evasion strategies, enabling these viruses to establish lifelong infections. Periods of immunosuppression can lead to severe disease, such as graft rejection, cancer, neurodegenerative disease and autoimmune diseases, which have been linked to herpesvirus infections. Consequently, developing strategies to prevent herpesvirus-associated diseases is a critical public health priority. However, varicella zoster virus (VZV) remains the only human herpesvirus for which licensed vaccines are available. This Review explores the mechanisms of humoral immune evasion by herpesviruses and their implications for advancing immunization and treatment strategies for chronic neurological, oncological and transplant-associated diseases caused by these common viral pathogens.
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Details
- Title
- Human herpesvirus evasion of humoral immunity and implications for vaccine development
- Creators
- Claire E. Otero - Cornell UniversityMatthew D. Slein - Dartmouth CollegeLibby Mitchell - Cornell UniversityAdarsh Ramloul - Drexel University, BiologyPhilipp Kolb - University Medical Center FreiburgMargaret E. Ackerman - Dartmouth CollegeSallie R. Permar - Cornell University
- Publication Details
- Nature reviews. Microbiology
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 15
- Grant note
- 2TL1-TR-238 / NIH/National Center for Advancing Translational Sciences (NCATS); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Michelson Research Foundation and Human Immunome Project U19AI145825; R01AI176646 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) DFG KO6815/1-1 / German Research Foundation; German Research Foundation (DFG) Office of Cyber Infrastructure and Computational Biology, NIAID Daedalus Fund for Innovation award from Weill Cornell Medicine R01-GM129325 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 3P01AI129859; 1R21AI176451 / National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:001713974500001
- Scopus ID
- 2-s2.0-105033953779
- Other Identifier
- 991022170455704721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology