Journal article
Human immunodeficiency virus infection of the developing human nervous system
Virology (New York, N.Y.), v 159(2), pp 440-445
1987
PMID: 3650007
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus (HIV), the etiologic agent of acquired immune deficiency syndrome (AIDS) and AIDS-related complex, has recently been implicated as a factor in the development of AIDS-related neurologic dysfunction and may be responsible for an increasing number of neonatal immunologic and neurologic disorders. However, as yet there is no model system available to investigate the interaction of HIV with the developing human nervous system
in vitro. To approximate the intracellular events associated with HIV infection of the human fetus nervous system we infected cells obtained by enzymatic dissociation of aborted human fetus dorsal root ganglia and their attached spinal roots and nerves. The expression of the HIV
gag gene protein products (p17 and p24) was detected in a subpopulation of cells with a nonneuronal morphology, reaching a maximum within 3 days. Although 70% of the nonneuronal cells were p17- and p24-positive 3 days after infection, a majority of the cell population survived acute HIV infection, with the expression of p17 and p24 decreasing below the limit of detection by 12 days postinfection. This system may prove useful for examining the neuropathology and neurobiology of acute, persistent, or latent HIV infection of the developing human nervous system.
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Details
- Title
- Human immunodeficiency virus infection of the developing human nervous system
- Creators
- Brian Wigdahl - Pennsylvania State UniversityRhonda A. Guyton - Pennsylvania State UniversityPrem S. Sarin - National Cancer Institute
- Publication Details
- Virology (New York, N.Y.), v 159(2), pp 440-445
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1987J462200028
- Scopus ID
- 2-s2.0-0023230252
- Other Identifier
- 991020111197504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology