Journal article
Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
Gastroenterology (New York, N.Y. 1943), v 135(1), pp 226-233
01 Jul 2008
PMID: 18457674
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background&Aims: Human immunodeficiency virus (HIV)-l infection has been associated with enhanced microbial translocation, and microbial translocation is a mechanism through which alcohol and some enteric conditions cause liver disease. We hypothesized that HIV promotes liver disease by enhancing microbial translocation. Methods: We studied human cohorts in which hepatitis C virus (HCV) and HIV outcomes were carefully characterized. Results: HIV-related CD4(+) lymphocyte depletion was strongly associated with microbial translocation as indicated by elevated levels of circulating hpopolysaccharide (LPS), LPS-binding protein, soluble CD14, and fucose-binding lectin (AAL) reactive to immunoglobulin G specific for the a-galactose epitope and suppressed levels of endotoxin core antibodies (EndoCAb IgM) in HIV-infected subjects compared with the same persons before they had HIV infection and compared with HIV-uninfected subjects. The same measures of microbial translocation were strongly associated with HCV-related liver disease progression (cirrhosis), eg, LPS, odds ratio, 19.0 (P =.002); AAL, odds ratio, 27.8 (P <.0001); in addition, levels of LPS were elevated prior to recognition of cirrhosis. Conclusions: Microbial translocation may be a fundamental mechanism through which HIV accelerates progression of chronic liver disease.
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Details
- Title
- Human immunodeficiency virus-related microbial translocation and progression of hepatitis C
- Creators
- Ashwin Balagopal - Johns Hopkins UniversityFrances H. Philp - Johns Hopkins UniversityJacquie Astemborski - Johns Hopkins UniversityTimothy M. Block - Drexel UniversityAnand Mehta - Drexel UniversityRonald Long - Drexel UniversityGregory D. Kirk - Johns Hopkins UniversityShruti H. Mehta - Johns Hopkins UniversityAndrea L. Cox - Johns Hopkins UniversityDavid L. Thomas - Johns Hopkins UniversityStuart C. Ray - Johns Hopkins University
- Publication Details
- Gastroenterology (New York, N.Y. 1943), v 135(1), pp 226-233
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- R01 DA012568; R01 DA013806-08; R01 2 DA012568; R01 DA011602-10; R37 DA004334-20; R01 DA012568-10; U01 DA036935; R01 DA016078; 1 R37DA004334; R01 DA013806; R01 DA016078-06; R56 DA004334; R01 DA011602; R37 DA004334 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) R01 AA016893 / NIAAA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R56DA004334 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01CA120206; U01 CA084951; R01 CA120206-02; R01 CA120206; U01 CA084951-09; U01CA084951 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01AA016893 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) T32AI007291 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32 AI07291; T32 AI007291; K08 AI081544 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U01CA084951 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000257551900030
- Scopus ID
- 2-s2.0-46049084182
- Other Identifier
- 991019167473204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology