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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
Nature immunology, v 17(8), pp 966-975
Aug 2016
PMID: 27270402
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The number of naive T cells decreases and susceptibility to new microbial infections increases with age. Here we describe a previously unknown subset of phenotypically naive human CD8(+) T cells that rapidly secreted multiple cytokines in response to persistent viral antigens but differed transcriptionally from memory and effector T cells. The frequency of these CD8(+) T cells, called 'memory T cells with a naive phenotype' (TMNP cells), increased with age and after severe acute infection and inversely correlated with the residual capacity of the immune system to respond to new infections with age. CD8(+) TMNP cells represent a potential new target for the immunotherapy of persistent infections and should be accounted for and subtracted from the naive pool if truly naive T cells are needed to respond to antigens.
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Details
- Title
- Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
- Creators
- Vesna Pulko - University of ArizonaJohn S Davies - University of ArizonaCarmine Martinez - University of ArizonaMarion C Lanteri - Blood Systems Research InstituteMichael P Busch - Blood Systems Research InstituteMichael S Diamond - Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USAKenneth Knox - University of ArizonaErin C Bush - Columbia University Irving Medical CenterPeter A Sims - Columbia University Irving Medical CenterShripad Sinari - University of ArizonaDean Billheimer - University of ArizonaElias K Haddad - Drexel UniversityKristy O Murray - Baylor College of MedicineAnne M Wertheimer - University of ArizonaJanko Nikolich-Žugich - University of Arizona
- Publication Details
- Nature immunology, v 17(8), pp 966-975
- Publisher
- Springer Nature
- Grant note
- P30 ES006694 / NIEHS NIH HHS RC2 HL101632 / NHLBI NIH HHS P30 AG008017 / NIA NIH HHS R01 AG048021 / NIA NIH HHS P30 CA023074 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Physician Assistant; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000380647000014
- Scopus ID
- 2-s2.0-84976298029
- Other Identifier
- 991020100204204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology