Journal article
Human placentas, optimal transportation and high-risk autism pregnancies
Journal of coupled systems and multiscale dynamics, v 4(4), pp 260-270
01 Dec 2016
Abstract
The aim of this article is to study the traced vascular structures inside (human) placentas via optimal transportation techniques from two groups of births-one from mothers who already have a child diagnosed with ASD and the other from a general-population birth cohort. Younger siblings of children diagnosed with ASD are themselves at several-fold greater risk of being diagnosed with ASD. Consequently, this comparison can provide an initial indication of whether placental vascularization might be deserving of further study in etiologic research on prenatal neuro development and as a potential ASD risk biomarker. Our results show that vascular structures quantified by transport efficiency in placentas belonging to newborns at higher ASD risk are significantly different from those in placentas from the population-based control cohort.
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Details
- Title
- Human placentas, optimal transportation and high-risk autism pregnancies
- Creators
- Qinglan Xia - Univ Calif Davis, Dept Math, One Shields Ave, Davis, CA 95616 USALisa A. Croen - Kaiser Permanente Northern Calif, Div Res, Oakland, CA 94612 USAM. Danielle Fallin - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Wendy Klag Ctr Autism & Dev Disabil, Baltimore, MD 21205 USACraig J. Newschaffer - Drexel UniversityCheryl Walker - Univ Calif Davis, MIND Inst, Dept Obstet & Gynecol, Sacramento, CA 95817 USAPhilip Katzman - Univ Rochester, Med Ctr, Rochester, NY 14642 USARichard K. Miller - Univ Rochester, Med Ctr, Rochester, NY 14642 USAJohn Moye - Natl Inst Child Hlth & Human Dev, Rockville, MD 20817 USASimon Morgan - Imperial Coll London, Dept Phys, London SW7 2AZ, EnglandCarolyn M. Salafia - Placental Analyt, New Rochelle, NY 10804 USA
- Publication Details
- Journal of coupled systems and multiscale dynamics, v 4(4), pp 260-270
- Publisher
- Amer Scientific Publishers
- Number of pages
- 11
- Grant note
- 9502 / Autism Speaks DMS-1109663 / NSF; National Science Foundation (NSF) R01HD39373-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA l R43HD062307- 01 / SBIR R01ES016443 / EARLI
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000402718500003
- Other Identifier
- 991019168215004721
InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Mechanics