Journal article
Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis
American journal of obstetrics and gynecology, v 201(2), pp 206.e1-206.e5
2009
PMID: 19646572
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We evaluated whether vaginal concentrations of hyaluronan were altered in women with recurrent vulvovaginal candidiasis (RVVC).
Lavage samples from 17 women with acute RVVC, 27 women who were receiving a maintenance antifungal regimen, and 24 control women were tested for hyaluronan and interleukin (IL)-6, IL-12, and IL-23 by enzyme-linked immunosorbent assay.
Median vaginal hyaluronan concentrations were 33.8 ng/mL (range, 21.6-66.3 ng/mL) in women with acute RVVC, 15.0 ng/mL (range, 11.2-50.6 ng/mL) in women who were receiving maintenance therapy, and 4.2 ng/mL (range, 3.6-12.0 ng/mL) in control subjects (
P ≤ .02). The vaginal hyaluronan concentration was 27.4 ng/mL (range, 15.4-37.7 ng/mL) when
Candida was detected by microscopy and 9.5 ng/mL (range, 7.7-14.6 ng/mL) in microscopy-negative cases (
P = .0354). Elevated hyaluronan levels were associated with itching plus burning (40.7 ng/mL) or itching plus discharge (42.1 ng/mL), as opposed to itching only (6.2 ng/mL;
P = .0152). Hyaluronan and IL-6 levels were correlated (
P = .0009).
Hyaluronan release is a component of the host response to a candidal infection and may contribute to symptoms.
Metrics
Details
- Title
- Hyaluronan in vaginal secretions: association with recurrent vulvovaginal candidiasis
- Creators
- Ahinoam Lev-Sagie - Cornell UniversityPaul Nyirjesy - Drexel UniversityNicholas Tarangelo - Cornell UniversityAnn Marie Bongiovanni - Cornell UniversityCynthia Bayer - Drexel UniversityIara M. Linhares - Universidade de São PauloPaulo C. Giraldo - Universidade Estadual de Campinas (UNICAMP)William J. Ledger - Cornell UniversitySteven S. Witkin - Cornell University
- Publication Details
- American journal of obstetrics and gynecology, v 201(2), pp 206.e1-206.e5
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000268460900028
- Scopus ID
- 2-s2.0-67651123032
- Other Identifier
- 991019350580004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology