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Journal article
Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease
Advanced drug delivery reviews, v 212, 115395
01 Aug 2024
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
•Hypersensitivity mechanisms underlie autoimmune disease development.•Treatments for autoimmunity focus on managing downstream effects & symptoms.•Targeting upstream mechanisms (e.g., self-tolerance) can prevent/eliminate disease.•Hydrogel-based drug delivery can improve outcomes and may minimize off-target effects.•Advances may be made through combinatorial therapies and smart material selection.
A robust adaptive immune response is essential for combatting pathogens. In the wrong context such as due to genetic and environmental factors, however, the same mechanisms crucial for self-preservation can lead to a loss of self-tolerance. Resulting autoimmunity manifests in the development of a host of organ-specific or systemic autoimmune diseases, hallmarked by aberrant immune responses and tissue damage. The prevalence of autoimmune diseases is on the rise, medical management of which focuses primarily on pharmacological immunosuppression that places patients at a risk of side effects, including opportunistic infections and tumorigenesis. Biomaterial-based drug delivery systems confer many opportunities to address challenges associated with conventional disease management. Hydrogels, in particular, can protect encapsulated cargo (drug or cell therapeutics) from the host environment, afford their presentation in a controlled manner, and can be tailored to respond to disease conditions or support treatment via multiplexed functionality. Moreover, localized delivery to affected sites by these approaches has the potential to concentrate drug action at the site, reduce off-target exposure, and enhance patient compliance by reducing the need for frequent administration. Despite their many benefits for the management of autoimmune disease, such biomaterial-based approaches focus largely on the downstream effects of hypersensitivity mechanisms and have a limited capacity to eradicate the disease. In contrast, direct targeting of mechanisms of hypersensitivity reactions uniquely enables prophylaxis or the arrest of disease progression by mitigating the basis of autoimmunity. One promising approach is to induce self-antigen-specific tolerance, which specifically subdues damaging autoreactivity while otherwise retaining the normal immune responses. In this review, we will discuss hydrogel-based systems for the treatment of autoimmune disease, with a focus on those that target hypersensitivity mechanisms head-on. As the field continues to advance, it will expand the range of therapeutic choices for people coping with autoimmune diseases, providing fresh prospects for better clinical outcomes and improved quality of life.
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Details
- Title
- Hydrogel-based approaches to target hypersensitivity mechanisms underlying autoimmune disease
- Creators
- Kenneth M. Kim - Drexel University, Microbiology and ImmunologyArielle M. D’Elia - Drexel University, School of Biomedical Engineering, Science, and Health SystemsChristopher B. Rodell (Corresponding Author) - Drexel University, School of Biomedical Engineering, Science, and Health Systems
- Publication Details
- Advanced drug delivery reviews, v 212, 115395
- Publisher
- Elsevier
- Number of pages
- 24
- Grants
- Designing supramolecular delivery strategies to understand and exploit synergies in immunoregenerative medicine, R35GM147184, National Institutes of Health (United States, Bethesda) - NIH
- Grant note
- Career Development Award from the American Heart Association: 23CDA1054367
The authors wish to thank Dr. Biplab Sarkar for critical review and assistance in editing of the manuscript. This work was supported by the National Institutes of Health (R35GM147184) and a Career Development Award (C.B.R.) from the American Heart Association (23CDA1054367; https://doi.org/10.58275/AHA.23CDA1054367.pc. gr.168006) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001286600500001
- Scopus ID
- 2-s2.0-85200218937
- Other Identifier
- 991021893412304721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy