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Published, Version of Record (VoR)CC BY-NC-SA V4.0, Open
Journal article
Hydrogel-based local drug delivery strategies for spinal cord repair
Neural regeneration research, v 16(2), pp 247-253
24 Aug 2020
PMID: 32859771
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Spinal cord injury results in significant loss of motor, sensory, and autonomic functions. Although a wide range of therapeutic agents have been shown to attenuate secondary injury or promote regeneration/repair in animal models of spinal cord injury, clinical translation of these strategies has been limited, in part due to difficulty in safely and effectively achieving therapeutic concentrations in the injured spinal cord tissue. Hydrogel-based drug delivery systems offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associated with systemic drug administration. Such local drug delivery systems can be readily fabricated from biocompatible and biodegradable materials. In this review, hydrogel-based strategies for local drug delivery to the injured spinal cord are extensively reviewed, and recommendations are made for implementation.
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Details
- Title
- Hydrogel-based local drug delivery strategies for spinal cord repair
- Creators
- Robert B. Shultz - Rutgers, The State University of New JerseyYinghui Zhong - Drexel University
- Publication Details
- Neural regeneration research, v 16(2), pp 247-253
- Publisher
- Wolters Kluwer - Medknow
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000573661500007
- Scopus ID
- 2-s2.0-85091040573
- Other Identifier
- 991019167343404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Neurosciences