Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy
ACS applied bio materials, v 7(5), pp 3041-3049
20 May 2024
PMID: 38661721
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drug-coated balloon (DCB) therapy is a promising endovascular treatment for obstructive arterial disease. The goal of DCB therapy is restoration of lumen patency in a stenotic vessel, whereby balloon deployment both mechanically compresses the offending lesion and locally delivers an antiproliferative drug, most commonly paclitaxel (PTX) or derivative compounds, to the arterial wall. Favorable long-term outcomes of DCB therapy thus require predictable and adequate PTX delivery, a process facilitated by coating excipients that promotes rapid drug transfer during the inflation period. While a variety of excipients have been considered in DCB design, there is a lack of understanding about the coating-specific biophysical determinants of essential device function, namely, acute drug transfer. We consider two hydrophilic excipients for PTX delivery, urea (UR) and poly(ethylene glycol) (PEG), and examine how compositional and preparational variables in the balloon surface spray-coating process impact resultant coating microstructure and in turn acute PTX transfer to the arterial wall. Specifically, we use scanning electron image analyses to quantify how coating microstructure is altered by excipient solid content and balloon-to-nozzle spray distance during the coating procedure and correlate obtained microstructural descriptors of coating aggregation to the efficiency of acute PTX transfer in a one-dimensional ex vivo model of DCB deployment. Experimental results suggest that despite the qualitatively different coating surface microstructures and apparent PTX transfer mechanisms exhibited with these excipients, the drug delivery efficiency is generally enhanced by coating aggregation on the balloon surface. We illustrate this microstructure–function relation with a finite element-based computational model of DCB deployment, which along with our experimental findings suggests a general design principle to increase drug delivery efficiency across a broad range of DCB designs.
Metrics
Details
- Title
- Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy
- Creators
- Tarek Shazly (Corresponding Author) - University of South CarolinaJohn F. Eberth - Drexel UniversityColton J. Kostelnik - Drexel UniversityMark J. Uline - University of South CarolinaVipul C. Chitalia - Boston UniversityFrancis G. Spinale - University of South CarolinaAhmed Alshareef - University of South CarolinaVijaya B. Kolachalama - Boston University
- Publication Details
- ACS applied bio materials, v 7(5), pp 3041-3049
- Publisher
- ACS Publications
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001229270600001
- Scopus ID
- 2-s2.0-85191804943
- Other Identifier
- 991021902499104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology