Journal article
Hydrophobic drug concentration affects the acoustic susceptibility of liposomes
Biochimica et biophysica acta, v 1850(4), pp 667-672
Apr 2015
PMID: 25450487
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this study was to investigate the effect of encapsulated hydrophobic drug concentration on ultrasound-mediated leakage from liposomes. Studies have shown that membrane modifications affect the acoustic susceptibility of liposomes, likely because of changes in membrane packing. An advantage of liposome as drug carrier is its ability to encapsulate drugs of different chemistries. However, incorporation of hydrophobic molecules into the bilayer may cause changes in membrane packing, thereby affecting the release kinetics. Liposomes containing calcein and varying concentrations of papaverine, a hydrophobic drug, were exposed to 20 kHz, 2.2 Wcm(-2) ultrasound. Papaverine concentration was observed to affect calcein leakage although the effects varied widely based on liposome phase. For example, incorporation of 0.5mg/mL papaverine into Ld liposomes increased the leakage of hydrophilic encapsulants by 3× within the first minute (p=0.004) whereas the same amount of papaverine increased leakage by only 1.5× (p<0.0001). Papaverine was also encapsulated into echogenic liposomes and its concentration did not significantly affect calcein release rates, suggesting that burst release from echogenic liposomes is predictable regardless of encapsulants chemistry and concentration.
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Details
- Title
- Hydrophobic drug concentration affects the acoustic susceptibility of liposomes
- Creators
- An T Nguyen - Drexel UniversityPeter A Lewin - Drexel UniversitySteven P Wrenn (Corresponding Author) - Drexel University
- Publication Details
- Biochimica et biophysica acta, v 1850(4), pp 667-672
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Chemical and Biological Engineering
- Web of Science ID
- WOS:000350191700010
- Scopus ID
- 2-s2.0-84921065008
- Other Identifier
- 991019168113704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics