Journal article
Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis
International journal of radiation oncology, biology, physics, v 84(3), pp 733-740
01 Nov 2012
PMID: 22440041
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic-and prostate-only radiotherapy.
Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15-84 years). The range of external-beam radiation delivered was 50.0-75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90-120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues-Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy.
Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7-70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1).
Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects. (C) 2012 Elsevier Inc.
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Details
- Title
- Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis
- Creators
- Caspian Oliai - Drexel UniversityBrandon Fisher - Drexel UniversityAshish Jani - Drexel UniversityMichael Wong - Drexel UniversityJaganmohan Poli - Drexel UniversityLuther W. Brady - Drexel UniversityLydia T. Komarnicky - Drexel University
- Publication Details
- International journal of radiation oncology, biology, physics, v 84(3), pp 733-740
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); [Retired Faculty]
- Web of Science ID
- WOS:000309560600058
- Scopus ID
- 2-s2.0-84866741846
- Other Identifier
- 991019168594404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging