Journal article
Hyperdiploidy with trisomy 9 and deletion of the CDKN2A locus in T-cell acute lymphoblastic leukemia
Cancer genetics and cytogenetics, v 190(2), pp 121-124
15 Apr 2009
PMID: 19380031
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We describe the rate finding of a T-cell acute lymphoblastic leukemia (T-ALL) and a pretreatment bone marrow karyotype mosaic for four distinct cell lines in a 4-year-old boy. G-banding analysis of metaphase cells identified a hyperdiploid cell fine (52 chromosomes) trisomic for chromosomes 6, 9, 11, 13, 19, and 22. Fluorescence in situ hybridization (FISH) analysis demonstrated that these hyperdiploid cells were missing all three copies of the CDKN2A locus (alias pl6/Ink4) at 9p21. FISH analysis of interphase nuclei identified two abnormal cell fines: the majority of cells with homozygous deletions of the CDKN2A locus and some with a heterozygous deletion. In addition, a normal signal pattern was identified in a few cells. This case represents a rare case of hyperdiploidy in T-ALL, and characterizes the clonal evolution of the 9p21 deletion leading, to the abnormal karyotype. (c) 2009 Elsevier Inc. All rights reserved.
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Details
- Title
- Hyperdiploidy with trisomy 9 and deletion of the CDKN2A locus in T-cell acute lymphoblastic leukemia
- Creators
- Kelley Healey - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical Pathology, Drexel University College of Medicine, St. Christopher's Hospital for Children, 3601 A Street, Philadelphia, PA 19134S. Lauren Gray - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical Pathology, Drexel University College of Medicine, St. Christopher's Hospital for Children, 3601 A Street, Philadelphia, PA 19134Gregory E. Halligan - St. Christopher's Hospital for ChildrenAnn S. McKenzie - St. Christopher's Hospital for ChildrenJean-Pierre de Chadarevian - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical Pathology, Drexel University College of Medicine, St. Christopher's Hospital for Children, 3601 A Street, Philadelphia, PA 19134Jennifer J. D. Morrissette - Department of Pathology and Laboratory Medicine, Sections of Cytogenetics and Anatomical Pathology, Drexel University College of Medicine, St. Christopher's Hospital for Children, 3601 A Street, Philadelphia, PA 19134
- Publication Details
- Cancer genetics and cytogenetics, v 190(2), pp 121-124
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000265775200012
- Scopus ID
- 2-s2.0-64749100715
- Other Identifier
- 991019168558904721
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InCites Highlights
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- Web of Science research areas
- Genetics & Heredity
- Oncology