Logo image
Back
Hyperresponsiveness of arterial rings induced by renal prehypertensive rabbit plasma
Journal article   Peer reviewed

Hyperresponsiveness of arterial rings induced by renal prehypertensive rabbit plasma

D. E. Dostal, J. A. Johnson, P. B. Langevin and N. Abas
American journal of physiology. Heart and circulatory physiology, v 255(2), pp H272-H279
01 Aug 1988
DOI: https://doi.org/10.1152/ajpheart.1988.255.2.H272
PMID: 3044142
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Vascular rings from normal rabbit renal arteries, when bathed in processed plasma from 3-day renal artery stenosis (RAS) rabbits, had greater contractile responses to norepinephrine than did matched rings bathed in processed plasma from sham-operated rabbits. This vascular hyperresponsiveness of the rings produced by 3-day RAS plasma was abolished by the angiotensin II (ANG II) antagonist [Sar1, Ile8] ANG II but not by [Sar1, Ala8] ANG II at a dose that completely blocked the contractile responses of the rings to ANG II. The addition of [Sar1, Ala8]-ANG II to rings bathed in normal rabbit plasma did not alter the contractile responses to norepinephrine, indicating a lack of agonistic action by this ANG II analogue. These studies demonstrated that the ANG II receptors involved in the hormonally mediated vascular hyperresponsiveness in 3-day RAS rabbits are contained in the tissues that comprise these renal arterial rings.

Metrics

6 Record Views
4 citations in Web of Science

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
Web of Science research areas
Physiology
Logo image