Journal article
Hypertension and risk of uterine leiomyomata in US black women
Human reproduction (Oxford), v 27(5), pp 1504-1509
01 May 2012
PMID: 22371286
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Abstract
Previous studies have found a positive association between hypertension and risk of hysterectomy-confirmed uterine leiomyomata (UL). The association of hypertension with UL confirmed by ultrasound or other surgery is less clear.
The present study evaluated the association of hypertension with UL incidence according to confirmation method (hysterectomy, other surgery or ultrasound) in the Black Womens Health Study, 19972007. We collected prospective data every 2 years on physician-diagnosed hypertension and UL in 22 530 premenopausal women. Validation sub-studies confirmed 99 and 96 of hypertension and UL self-reported diagnoses, respectively. Cox regression was used to estimate incidence rate ratios (IRRs) and 95 confidence intervals (CIs) for the association of hypertension and UL, adjusting for potential confounders.
During 172 162 person-years of follow-up, there were 6447 incident cases of UL confirmed by ultrasound (n 5111), hysterectomy (n 670) or other surgery (n 666). Treated hypertension was associated with UL confirmed by hysterectomy (IRR 1.32, 95 CI: 1.06, 1.63), but it was not associated with UL confirmed by ultrasound (IRR 1.05, 95 CI: 0.96, 1.16) or other surgery (IRR 1.13, 95 CI: 0.88, 1.46).
Treated hypertension was associated with UL confirmed by hysterectomy, but not UL confirmed by other methods (other surgery or ultrasound). These data suggest it is premature to conclude that hypertension is related to an increased risk of UL. Additional studies are needed to assess whether the association with hysterectomy-confirmed UL can be explained by other sources of bias, such as patient or physician preferences for specific types of medical care.
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Details
- Title
- Hypertension and risk of uterine leiomyomata in US black women
- Creators
- R. G. Radin - Boston UniversityL. Rosenberg - Boston UniversityJ. R. Palmer - Boston UniversityY. C. Cozier - Boston UniversityS. K. Kumanyika - University of PennsylvaniaL. A. Wise - Boston University
- Publication Details
- Human reproduction (Oxford), v 27(5), pp 1504-1509
- Publisher
- Oxford Univ Press
- Number of pages
- 6
- Grant note
- CA058420; HD055211 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01CA058420 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R03HD055211 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Dana and David Dornsife School of Public Health
- Web of Science ID
- WOS:000303161900034
- Scopus ID
- 2-s2.0-84860205075
- Other Identifier
- 991019312614304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Reproductive Biology