Journal article
Hypertonic saline in non–cystic fibrosis bronchiectasis (Hyper-BRONCHI): an updated systematic review and meta-analysis
BMC pulmonary medicine, v 26(1), 122
12 Feb 2026
PMID: 41673600
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Question: Does inhaled hypertonic saline (HS) provide better lung function outcomes for patients with non-cystic fibrosis bronchiectasis (non-CF bronchiectasis) ? Finding: Overall, hypertonic saline (HS) yielded outcomes comparable to those of the non-HS group (including isotonic saline or standard of care) with respect to FEV₁, FVC, and the annual number of pulmonary exacerbations. These findings were consistent during long-term follow-up of up to 52 weeks. Meaning: Up to date, the data on HS inhaled therapy for non-CF bronchiectasis is limited in high-quality studies, highlighting the need for further non-CF bronchiectasis-specific RCTs, focusing on HS of NaCl 6–7%.
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Details
- Title
- Hypertonic saline in non–cystic fibrosis bronchiectasis (Hyper-BRONCHI): an updated systematic review and meta-analysis
- Creators
- Nhan Nguyen - University of DebrecenYacin Zawam - Southern Ohio Medical CenterNghi Bao Tran - University of DebrecenNathalia Alves de Barros e Lyra - Faculdade Frassinetti do RecifeVinh Quang Tri Ho - Egyetem ter 1, Debrecen, 4032 HungaryDavid Downes - University of New EnglandVy Ngoc Dan Nguyen - The University of MelbourneHa Duc Thien Le - University of DebrecenJafar Aljazeeri - Drexel University, Pulmonary, Critical Care, and Sleep (Medicine)
- Publication Details
- BMC pulmonary medicine, v 26(1), 122
- Publisher
- BMC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:001717781000001
- Scopus ID
- 2-s2.0-105033483060
- Other Identifier
- 991022170438204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Respiratory System