Journal article
Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
Psychopharmacology (Berlin, Germany), v 214(2), pp 415-426
Mar 2011
PMID: 20959967
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent evidence indicates that the hypocretin/orexin system participates in the regulation of reinforcement and addiction processes. For example, manipulations that decrease hypocretin neurotransmission result in disruptions of neurochemical and behavioral responses to cocaine.
To further assess the relationship between the hypocretin system and cocaine reinforcement, the current studies used microdialysis and in vivo voltammetry to examine the effects of hypocretin 1 on cocaine-induced enhancement of dopamine signaling in the nucleus accumbens core. Fixed ratio, discrete trials, and progressive ratio self-administration procedures were also used to assess whether hypocretin 1 promotes cocaine self-administration behavior.
Infusions of hypocretin 1 into the ventral tegmental area increased the effects of cocaine on tonic and phasic dopamine signaling and increased the motivation to self-administer cocaine on the discrete trials and progressive ratio schedules.
Together with previous observations demonstrating that a hypocretin 1 receptor antagonist disrupts dopamine signaling and reduces self-administration of cocaine, the current observations further indicate that the hypocretin system participates in reinforcement processes likely through modulation of the mesolimbic dopamine system.
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Details
- Title
- Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
- Creators
- Rodrigo A España - Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA. respana@wfubmc.eduJames R MelchiorDavid C S RobertsSara R Jones
- Publication Details
- Psychopharmacology (Berlin, Germany), v 214(2), pp 415-426
- Publisher
- Springer Nature; Germany
- Grant note
- R01 DA021325-04 / NIDA NIH HHS K01 DA025279-01 / NIDA NIH HHS R01 DA14030 / NIDA NIH HHS P50 DA006634 / NIDA NIH HHS P50 DA006634-15 / NIDA NIH HHS R01 DA021325 / NIDA NIH HHS R01 DA030161 / NIDA NIH HHS R01 DA014030 / NIDA NIH HHS K01 DA025279 / NIDA NIH HHS R01 DA014030-08 / NIDA NIH HHS P50 DA06634 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000287759500005
- Scopus ID
- 2-s2.0-79952282709
- Other Identifier
- 991014877951304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry