Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep
Behavioural brain research, v 291, pp 377-384
15 Sep 2015
PMID: 26049058
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent evidence suggests that blockade of the hypocretin receptor 1 may act as a useful pharmacotherapy for cocaine abuse. Here we investigated the extent to which various doses of a hypocretin receptor 1 antagonist, SB-334867, affect cocaine self-administration at varying doses of cocaine and across a range of effort requirements, and tested if these SB-334867 doses produce sedative effects. First, we trained animals to self-administer one of three doses of cocaine on a progressive ratio schedule, and then tested the effects of three doses of SB-334867. Responding for cocaine was then analyzed to segregate features of relatively high and low effort requirements across the progressive ratio session. In another set of experiments, we tested potential sleep-promoting effects of the same doses of SB-334867. Our data indicate that blockade of hypocretin receptor 1 preferentially reduces high effort responding for cocaine at levels that do not promote sedation. (C) 2015 Elsevier B.V. All rights reserved.
Metrics
Details
- Title
- Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep
- Creators
- Zachary D. Brodnik - Drexel UniversityDavid L. Bernstein - Drexel UniversityCourtney D. Prince - Drexel UniversityRodrigo A. Espana - Drexel University
- Publication Details
- Behavioural brain research, v 291, pp 377-384
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- R01DA025279 / United states National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) R01DA031900 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000358454800046
- Scopus ID
- 2-s2.0-84931264351
- Other Identifier
- 991019167832704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Neurosciences