Journal article
Hypocretin receptor 1 involvement in cocaine-associated behavior: Therapeutic potential and novel mechanistic insights
Brain research, v 1731, pp 145894-145894
15 Mar 2020
PMID: 30071195
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Since its discovery in 1998, the hypocretin/orexin system has been identified as a critical modulator of behavior. Through interactions with dopamine neurons of the ventral tegmental area, this system is poised to regulate motivation for drug rewards by impacting dopamine neurotransmission in target structures including the nucleus accumbens. Across numerous experiments, we and others have identified a critical influence of hypocretin receptor 1 in mediating the behavioral and physiological effects of cocaine which positions this receptor as a potential target for the treatment of cocaine addiction. Here we discuss evidence for hypocretin receptor 1 involvement in driving cocaine-associated behavior and how hypocretin receptor 1 in the ventral tegmental area are critical for supporting dopamine neuron activity and dopamine neurotransmission. We then present new data supporting the novel hypothesis that in addition to exerting acute actions on dopamine systems, pharmacological hypocretin manipulations also produce lasting adaptations to dopamine terminals that impact sensitivity to cocaine, and ultimately, future behavior.
Metrics
Details
- Title
- Hypocretin receptor 1 involvement in cocaine-associated behavior: Therapeutic potential and novel mechanistic insights
- Creators
- Zachary D. Brodnik - Drexel UniversityI. Pamela Alonso - Drexel UniversityWei Xu - Drexel UniversityYanan Zhang - RTI InternationalSandhya Kortagere - Drexel UniversityRodrigo A. Espana - Drexel University
- Publication Details
- Brain research, v 1731, pp 145894-145894
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- F31DA042505 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01DA031900; R01DA032837; F31DA042505 / National Institutes on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000524456000007
- Scopus ID
- 2-s2.0-85051386551
- Other Identifier
- 991019167658204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences