Journal article
Hypocretin/orexin in arousal and stress
Brain research, v 1314, pp 91-102
2010
PMID: 19748490
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Multiple lines of evidence indicate that hypocretin/orexin (HCRT) participates in the regulation of arousal and arousal-related process. For example, HCRT axons and receptors are found within a variety of arousal-related systems. Moreover, when administered centrally, HCRT exerts robust wake-promoting actions. Finally, a dysregulation of HCRT neurotransmission is associated with the sleep/arousal disorder, narcolepsy. Combined, these observations suggested that HCRT might be a key transmitter system in the regulation of waking. Nonetheless, subsequent evidence indicates that HCRT may not play a prominent role in the initiation of normal waking. Instead HCRT may participate in a variety of processes such as consolidation of waking and/or coupling metabolic state with behavioral state. Additionally, substantial evidence suggests a potential involvement of HCRT in high-arousal conditions, including stress. Thus, HCRT neurotransmission is closely linked to high-arousal conditions, including stress, and HCRT administration exerts a variety of stress-like physiological and behavioral effects that are superimposed on HCRT-induced increases in arousal. Combined, this evidence suggests the hypothesis that HCRT may participate in behavioral responding under high-arousal aversive conditions. Importantly, these actions of HCRT may not be limited to stress. Like stress, appetitive conditions are associated with elevated arousal levels and a stress-like activation of various physiological systems. These and other observations suggest that HCRT may, at least in part, exert affectively neutral actions that are important under high-arousal conditions associated with elevated motivation and/or need for action.
Metrics
Details
- Title
- Hypocretin/orexin in arousal and stress
- Creators
- Craig W Berridge - Department of Psychology, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USARodrigo A España - Wake Forest University Health Sciences, Winston-Salem, NC 27157, USANicole M Vittoz - Koerner Pavilion, University of British Columbia Hospital, Vancouver, British Columbia, Canada V6T
- Publication Details
- Brain research, v 1314, pp 91-102
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000275312400009
- Scopus ID
- 2-s2.0-75449107169
- Other Identifier
- 991014878099804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences