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Journal article
Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms
Frontiers in behavioral neuroscience, v 6(AUGUST), pp 54-54
21 Aug 2012
PMID: 22933994
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The hypocretins/orexins are comprised of two neuroexcitatory peptides that are synthesized exclusively within a circumscribed region of the lateral hypothalamus. These peptides project widely throughout the brain and interact with a variety of regions involved in the regulation of arousal-related processes including those associated with motivated behavior. The current review focuses on emerging evidence indicating that the hypocretins influence reward and reinforcement processing via actions on the mesolimbic dopamine system. We discuss contemporary perspectives of hypocretin regulation of mesolimbic dopamine signaling in both drug free and drug states, as well as hypocretin regulation of behavioral responses to drugs of abuse, particularly as it relates to cocaine.
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Details
- Title
- Hypocretin/orexin regulation of dopamine signaling: implications for reward and reinforcement mechanisms
- Creators
- Erin S. Calipari - Wake Forest UniversityRodrigo A. Espana - Drexel University
- Publication Details
- Frontiers in behavioral neuroscience, v 6(AUGUST), pp 54-54
- Publisher
- Frontiers Media Sa
- Number of pages
- 13
- Grant note
- National Alliance on Schizophrenia and Depression K01DA025279 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission DA025279; DA021325 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000308429200001
- Scopus ID
- 2-s2.0-84864953752
- Other Identifier
- 991019168098804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Neurosciences