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Journal article
Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry
Scientific reports, v 10(1), pp 5447-5447
25 Mar 2020
PMID: 32214129
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Quantitative magnetic resonance imaging (MRI) investigations of brain anatomy in children and young adults with Down syndrome (DS) are limited, with no diffusion tensor imaging (DTI) studies covering that age range. We used DTI-driven tensor based morphometry (DTBM), a novel technique that extracts morphometric information from diffusion data, to investigate brain anatomy in 15 participants with DS and 15 age- and sex-matched typically developing (TD) controls, ages 6-24 years (mean age ~17 years). DTBM revealed marked hypoplasia of cerebellar afferent systems in DS, including fronto-pontine (middle cerebellar peduncle) and olivo-cerebellar (inferior cerebellar peduncle) connections. Prominent gray matter hypoplasia was observed in medial frontal regions, the inferior olives, and the cerebellum. Very few abnormalities were detected by classical diffusion MRI metrics, such as fractional anisotropy and mean diffusivity. Our results highlight the potential importance of cerebro-cerebellar networks in the clinical manifestations of DS and suggest a role for DTBM in the investigation of other brain disorders involving white matter hypoplasia or atrophy.
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Details
- Title
- Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry
- Creators
- Nancy Raitano Lee - Drexel UniversityAmritha Nayak - National Institute of Biomedical Imaging and BioengineeringM Okan Irfanoglu - National Institute of Biomedical Imaging and BioengineeringNeda Sadeghi - National Institute of Biomedical Imaging and BioengineeringCatherine J Stoodley - American UniversityElizabeth Adeyemi - Alabama College of Osteopathic MedicineLiv S Clasen - National Institute of Mental HealthCarlo Pierpaoli - National Institute of Biomedical Imaging and Bioengineering
- Publication Details
- Scientific reports, v 10(1), pp 5447-5447
- Publisher
- Springer Nature
- Grant note
- ZIA MH002794 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000560015500003
- Scopus ID
- 2-s2.0-85082483311
- Other Identifier
- 991019167960604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences