Journal article
Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations
Journal of thyroid research, v 2016(2016), pp 10-16
01 Jan 2016
PMID: 27123358
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival. To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage (P < 0.05). Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion (P < 0.05). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer.
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Details
- Title
- Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations
- Creators
- Konrad Sarosiek - Thomas Jefferson UniversityAnkit V. Gandhi - Thomas Jefferson UniversityShivam Saxena - Thomas Jefferson UniversityChristopher Y. Kang - Thomas Jefferson UniversityGalina I. Chipitsyna - University of New EnglandCharles J. Yeo - Thomas Jefferson UniversityHwyda A. Arafat - University of New England
- Publication Details
- Journal of thyroid research, v 2016(2016), pp 10-16
- Publisher
- Hindawi Publishing Group
- Number of pages
- 7
- Grant note
- Department of Biomedical Sciences, University of New England, Biddeford, ME Department of Surgery, Thomas Jefferson University Hospital, Philadelphia, PA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000374061100001
- Scopus ID
- 2-s2.0-84971402186
- Other Identifier
- 991022047280904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism