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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells
Journal of cellular biochemistry, v 117(2), pp 267-278
Feb 2016
PMID: 26206147
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIF-1 activation has been well known as an adaptive strategy to hypoxia. Recently it became clear that hypoxia was often accompanied by insufficient supply of glucose or amino acids as a common result of poor circulation that frequently occurs in solid tumors and ischemic lesions, creating a mixed nutrient insufficiency. In response to nutrient insufficiency, stressed cells elicit survival strategies including activation of AMPK and HIF-1 to cope with the stress. Particularly, in solid tumors, HIF-1 promotes cell survival and migration, stimulates angiogenesis, and induces resistance to radiation and chemotherapy. Interestingly, radiation and some chemotherapeutics are reported to trigger the activation of AMPK. Here we discuss the recent advances that may potentially link the stress responsive mechanisms including AMPK activation, ATF4 activation and the enhancement of Hsp70/Hsp90 function to HIF-1 activation. Potential implication and application of the stress-facilitated HIF-1 activation in solid tumors and ischemic disorders will be discussed. A better understanding of HIF-1 activation in cells exposed to stresses is expected to facilitate the design of therapeutic approaches that specifically modulate cell survival strategy.
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Details
- Title
- Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells
- Creators
- Shuyang Chen - Florida State UniversityNianli Sang - Drexel University
- Publication Details
- Journal of cellular biochemistry, v 117(2), pp 267-278
- Publisher
- Wiley
- Grant note
- R01-CA129494 / NCI NIH HHS R01 CA129494 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000368229900001
- Scopus ID
- 2-s2.0-84970924674
- Other Identifier
- 991019167937504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology