Journal article
Hypoxia and Inflammation in Children with Sickle Cell Disease: Implications for Hippocampal Functioning and Episodic Memory
Neuropsychology review, v 24(2), pp 252-265
01 Jun 2014
PMID: 24744195
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Children with sickle cell disease (SCD) suffer from systemic processes (e.g., chronic anemia, recurrent hypoxic-ischemic events, chronic inflammation) that have been associated with neurocognitive impairment in a range of clinical populations, but which have been largely understudied in relation to specific domains of cognitive functioning in children with SCD. This review focuses on episodic memory, as the hippocampus may be especially vulnerable to the systemic processes associated with SCD. The first part of the paper outlines the pathophysiology of SCD and briefly reviews the extant literature on academic and cognitive functioning in children with SCD, emphasizing the dearth of research on episodic memory. Next, the complex systemic processes of hypoxia and inflammation associated with SCD are reviewed, along with research that has associated these processes with hippocampal damage and memory impairment. The paper concludes with suggestions for future research that are informed, in part, by the literature on developmental amnesia.
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Details
- Title
- Hypoxia and Inflammation in Children with Sickle Cell Disease: Implications for Hippocampal Functioning and Episodic Memory
- Creators
- Mary Iampietro - Temple UniversityTania Giovannetti - Temple UniversityReem Tarazi - Drexel University
- Publication Details
- Neuropsychology review, v 24(2), pp 252-265
- Publisher
- Springer Nature
- Number of pages
- 14
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:000335812700010
- Scopus ID
- 2-s2.0-84904249119
- Other Identifier
- 991021897314604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Psychology, Clinical