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Hypoxia-induced Ca2+-influx in cerebral cortical neuronal nuclei of newborn piglets
Journal article   Peer reviewed

Hypoxia-induced Ca2+-influx in cerebral cortical neuronal nuclei of newborn piglets

Maria Delivoria-Papadopoulos, Waseem Akhter and Om P Mishra
Neuroscience letters, v 342(1-2)
15 May 2003
DOI: https://doi.org/10.1016/S0304-3940(03)00256-8
PMID: 12727332
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adenosine Triphosphate - metabolism Animals Animals, Newborn Calcium - metabolism Cerebral Cortex - metabolism Hypoxia, Brain - metabolism Neurons - metabolism Phosphocreatine - metabolism Swine
The present study was designed to investigate the effect of hypoxia on nuclear calcium-influx in the cerebral cortex of newborn piglets. Anesthetized and ventilated newborn piglets divided into normoxic (n=4) and hypoxic groups with varying degrees of tissue hypoxia (n=10) were studied. Nuclear Ca(2+)-influx was determined using (45)Ca(2+) and plotted against ATP and phosphocreatine levels. The plots were analyzed by non-linear regression (exponential) analysis that showed a curvilinear relationship (r=0.92 for ATP and r=0.88 for phosphocreatine). These data suggest a threshold at which there is a sudden increase in the nuclear calcium-influx that then continues to increase with further decrease in the ATP and phosphocreatine levels. The results demonstrate an increase in the nuclear Ca(2+)-influx during hypoxia in newborn piglets and that this increase correlates in a curvilinear fashion with the increase in the degree of cerebral tissue hypoxia. We propose that the hypoxia-induced increase in intranuclear Ca(2+) is due to altered nuclear membrane Ca(2+)-influx mechanisms and will lead to Ca(2+)-mediated alteration of apoptotic gene expression as well as Ca(2+)-dependent activation of endonucleases that result in DNA fragmentation and subsequent programmed neuronal cell death.

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24 citations in Web of Science
27 citations in Scopus

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