Logo image
Back
ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity
Journal article   Open access   Peer reviewed

ICOS-B7 homologous protein interactions are necessary for mercury-induced autoimmunity

Yan Zheng, Monika Jost, John P Gaughan, Reiner Class, Anthony J Coyle and Marc Monestier
The Journal of immunology (1950), v 174(5), pp 3117-3121
01 Mar 2005
DOI: https://doi.org/10.4049/jimmunol.174.5.3117
PMID: 15728528
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4049/jimmunol.174.5.3117View
Published, Version of Record (VoR) Open

Abstract

Inducible T-Cell Co-Stimulator Protein Antibodies, Antinuclear - biosynthesis Membrane Glycoproteins - metabolism Mice, Inbred A Immunoglobulin E - biosynthesis Antibodies, Blocking - administration & dosage Antigens, CD - metabolism Autoimmune Diseases - genetics CD4-Positive T-Lymphocytes - immunology B7-2 Antigen Membrane Glycoproteins - physiology Immunoglobulin G - biosynthesis CD8-Positive T-Lymphocytes - metabolism Female Mice, Inbred DBA Genetic Predisposition to Disease Antigens, Differentiation, T-Lymphocyte - immunology Mice, Inbred C57BL CD4-Positive T-Lymphocytes - metabolism Antigens, Differentiation, T-Lymphocyte - metabolism B7-1 Antigen - physiology Autoimmune Diseases - prevention & control B7-1 Antigen - metabolism Animals Antibodies, Monoclonal - administration & dosage Down-Regulation - immunology Immune Tolerance - genetics Mercuric Chloride - toxicity Antigens, CD - physiology Mice Antigens, Differentiation, T-Lymphocyte - biosynthesis Autoimmune Diseases - chemically induced CD8-Positive T-Lymphocytes - immunology
After exposure to subtoxic doses of heavy metals such as mercury, H-2(s) mice develop an autoimmune syndrome consisting of the rapid production of IgG autoantibodies that are highly specific for nucleolar autoantigens and a polyclonal increase in serum IgG1 and IgE. In this study, we explore the role of one of the members of the CD28-B7 costimulation families, ICOS-B7 homologous protein (B7h), in the regulation of mercury-induced autoimmunity. The expression of ICOS on T cells was more enhanced in susceptible A.SW mice than in non-responsive C57BL/6 and DBA/2 mice after HgCl(2) treatment. Furthermore, in A.SW mice treated with HgCl(2), administration of a blocking anti-ICOS Ab effectively inhibited anti-nucleolar autoantibodies and total serum IgE production. Taken together, these results indicate that the ICOS-B7h costimulation pathway is required for this autoimmune syndrome and suggest that targeting this pathway might have therapeutic benefits for human autoimmune diseases.

Metrics

24 Record Views
21 citations in Web of Science
26 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Industry collaboration
Domestic collaboration
Web of Science research areas
Immunology
Logo image