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IL-10 mediates susceptibility to Trypanosoma cruzi infection
Journal article   Open access   Peer reviewed

IL-10 mediates susceptibility to Trypanosoma cruzi infection

S Reed, C E Brownell, D Russo, J Silva, K H Grabstein and P Morrissey
The Journal of immunology (1950), v 153(7), pp 3135-3140
01 Oct 1994
DOI: https://doi.org/10.4049/jimmunol.153.7.3135
PMID: 8089491
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.4049/jimmunol.153.7.3135View
Published, Version of Record (VoR) Open

Abstract

Trypanosoma cruzi
IL-10 has been shown to inhibit some aspects of macrophage activation, including the in vitro IFN- gamma -mediated intracellular killing of the protozoan parasite Trypanosoma cruzi. We have previously shown that genetically susceptible mice produced more IL-10 during T. cruzi infection than resistant mice, suggesting an association between IL-10 production and disease susceptibility. In the present study, such an association was documented. IL-10 mRNA was present in the spleens of susceptible C57BL/6 mice, but not in resistant (C57BL/6 x DBA/2) F1 mice, as early as 2 days after infection with T. cruzi. In susceptible mice, IL-10 mRNA was found in enriched populations of splenic T cells and peritoneal macrophages by 4 days after infection. By 14 days after infection, IL-10 mRNA was detected in enriched populations of splenic T cells and peritoneal macrophages, as well as by splenic B cells and macrophages. In SCID mice infected with T. cruzi, IL-10 mRNA was detected in peritoneal cells 2 days after infection. The IL-10 mRNA production was not abolished by treatment with anti-asialo GM-1 Ab before infection, which is consistent with its production by macrophages. Finally, the role of endogenous IL-10 production in the susceptibility to T. cruzi infection was demonstrated by the protection of highly susceptible C57BL/6 mice against acute disease and death from T. cruzi by the administration of neutralizing anti-IL-10 mAb. This study demonstrated an important and perhaps essential role of IL-10 in mediating in vivo susceptibility to T. cruzi infection.

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Immunology
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