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Journal article
IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques
Blood, v 118(9), pp 2520-2529
01 Sep 2011
PMID: 21757617
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus (HIV) infection is characterized by a progressive loss of memory CD4
+
T cells in multiple tissues, especially at mucosal surfaces where most of these cells reside. Although antiretroviral therapy (ART) suppresses viral replication and promotes the recovery of peripheral CD4
+
T cells, HIV-infected patients fail to fully reconstitute the CD4
+
T-cell pool at mucosal sites. IL-15 has been shown to preferentially expand memory-phenotype T cells and promote their migration to nonlymphoid tissues. Here we examined IL-15 treatment in combination with highly active ART in chronically SIV-infected rhesus macaques and found that IL-15 delayed viral suppression and failed to enhance ART-induced total and antigen-specific CD4
+
T-cell reconstitution at mucosal and lymphoid sites. IL-15 was able to induce the transient proliferation of SIV-specific, CMV-specific, and total memory CD8
+
T cells, but not of SIV-specific or total CD4
+
T cells. Moreover, upon treatment interruption, macaques receiving combined IL-15+ART lost CD4
+
T cells faster than those receiving ART alone. These results suggest that the combination of IL-15 with highly active ART is not more efficient than ART alone in promoting CD4
+
T-cell recovery in HIV-infected individuals and may accelerate CD4+ T-cell loss after treatment interruption.
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Details
- Title
- IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques
- Creators
- Enrico Lugli - National Institute of Allergy and Infectious DiseasesYvonne M. Mueller - Drexel UniversityMark G. Lewis - BioqualFrancois Villinger - Emory University School of MedicinePeter D. Katsikis - Drexel UniversityMario Roederer - National Institute of Allergy and Infectious Diseases
- Publication Details
- Blood, v 118(9), pp 2520-2529
- Publisher
- American Society of Hematology
- Grant note
- R01 AI046719; R21 AI082680; R24RR016988 / National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000294476400024
- Scopus ID
- 2-s2.0-80052413595
- Other Identifier
- 991019339573304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Hematology