Journal article
IL-15 in HIV infection: pathogenic or therapeutic potential?
EUROPEAN CYTOKINE NETWORK, v 21(3), pp 219-221
01 Sep 2010
PMID: 20719708
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent studies have shown that interleukin-15 (IL-15) is produced during acute HIV and SIV infection, and may impact viremia and viral set point. This is further supported by the findings that administration of IL-15 during acute SIV infection dramatically increases viral set point. Although the role of intrinsic IL-15 during chronic infection is much less defined, in vivo administration of IL-15 does not increase viral replication in SIV-infected animals. Recent data also suggest that IL-15 acts, not only on CD8+ T cells and natural killer cells, but also on effector memory CD4+ T cells. IL-15 clearly expands very different CD4+ T cell subpopulations than IL-2 in SIV-infected animals, and may be useful for the restoration of effector memory CD4+ T cells that are depleted early in HIV and SIV infection. Understanding IL-15' s role in SIV infection may help us to design novel therapeutic approaches to HIV infection.
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Details
- Title
- IL-15 in HIV infection: pathogenic or therapeutic potential?
- Creators
- Yvonne M. Mueller - Drexel UniversityPeter D. Katsikis - Drexel University
- Publication Details
- EUROPEAN CYTOKINE NETWORK, v 21(3), pp 219-221
- Publisher
- John Libbey Eurotext Ltd
- Number of pages
- 3
- Grant note
- R01 AI 46719; AI 62437 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AI062437 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000281962000011
- Scopus ID
- 2-s2.0-77957335238
- Other Identifier
- 991019339694704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology